Splice-variant-specific effects of primary aldosteronism point mutations on human CaV3.2 calcium channels.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.102104
Abstract: CaV3.2 calcium channels play important roles in both neural excitability and aldosterone secretion. Recent clinical studies found four germline mutations (S196 L, M1549I, V1951E and P2083 L) in CaV3.2 channels. All four mutations caused primary aldosteronism (PA),… read more here.
Keywords: splice; calcium channels; cav3 channels; cav3 calcium ... See more keywords
Putative Synthetic Cannabinoids MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T-Type Calcium Channel (CaV3) Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00822
Abstract: Synthetic cannabinoid receptor agonists (SCRAs) are a large and growing class of new psychoactive substances (NPSs). Two recently identified compounds, MEPIRAPIM and 5F-BEPIRAPIM (NNL-2), have not been confirmed as agonists of either cannabinoid receptor subtype… read more here.
Keywords: cav3 inhibitors; cav3; type calcium; bepirapim nnl ... See more keywords
Icariside II, a Prenyl-Flavonol, Alleviates Inflammatory and Neuropathic Pain by Inhibiting T-Type Calcium Channels and USP5-Cav3.2 Interactions.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00083
Abstract: Cav3.2 channels play an important role in the afferent nociceptive pathway, which is responsible for both physiological and pathological pain transmission. Cav3.2 channels are upregulated during neuropathic pain or peripheral inflammation in part due to… read more here.
Keywords: cav3 channels; cav3; neuropathic pain; pain ... See more keywords
The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11591-5
Abstract: Low-voltage-activated T-type calcium channels are essential contributors to the functioning of thalamocortical neurons by supporting burst-firing mode of action potentials. Enhanced T-type calcium conductance has been reported in the Genetic Absence Epilepsy Rat from Strasbourg… read more here.
Keywords: absence; calnexin; cav3; absence epilepsy ... See more keywords
A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52194-6
Abstract: Cav3 / T-type Ca2+ channels are dynamically regulated by intracellular Ca2+ ions, which inhibit Cav3 availability. Here, we demonstrate that this inhibition becomes irreversible in the presence of non-hydrolysable ATP analogs, resulting in a strong… read more here.
Keywords: mechanism; cav3; type ca2; ca2 ... See more keywords
The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is Regulated by the Epidermal Growth Factor Receptor via the MAPK Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Current eye research"
DOI: 10.1080/02713683.2021.1988982
Abstract: PURPOSE Retinoblastoma is the most frequent intraocular cancer in children. It is also one of the most common causes for enucleation and carries a significant morbidity rate in affected individuals. Hence, studies on its pathophysiological… read more here.
Keywords: y79 retinoblastoma; retinoblastoma; mapk signaling; cav3 ... See more keywords
Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia.
Sign Up to like & getrecommendations! Published in 2019 at "Cerebral cortex"
DOI: 10.1093/cercor/bhz002
Abstract: Although the central medial nucleus (CeM) of the thalamus is an essential part of the arousal system for sleep and anesthesia initiation, the precise mechanisms that regulate its activity are not well studied. We examined… read more here.
Keywords: cav3 isoform; central medial; induced anesthesia; cav3 ... See more keywords
CaV3.2 calcium channels contribute to trigeminal neuralgia.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002651
Abstract: ABSTRACT Trigeminal neuralgia (TN) is a rare but debilitating disorder characterized by excruciating facial pain, with a higher incidence in women. Recent studies demonstrated that TN patients present mutations in the gene encoding the CaV3.2… read more here.
Keywords: calcium; trigeminal neuralgia; function; cav3 ... See more keywords
Age attenuates the T‐type CaV3.2‐RyR axis in vascular smooth muscle
Sign Up to like & getrecommendations! Published in 2020 at "Aging Cell"
DOI: 10.1111/acel.13134
Abstract: Caveolae position CaV3.2 (T‐type Ca2+ channel encoded by the α‐3.2 subunit) sufficiently close to RyR (ryanodine receptors) for extracellular Ca2+ influx to trigger Ca2+ sparks and large‐conductance Ca2+‐activated K+ channel feedback in vascular smooth muscle.… read more here.
Keywords: ca2 sparks; cav3 ryr; cav3; smooth muscle ... See more keywords
Constitutive activity of the dopamine (D5) receptor, highly expressed in CA1 hippocampal neurons, selectively reduces CaV3.2 and CaV3.3 currents
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.16006
Abstract: CaV3.1‐3 currents differentially contribute to neuronal firing patterns. CaV3 are regulated by G protein‐coupled receptors (GPCRs) activity, but information about CaV3 as targets of the constitutive activity of GPCRs is scarce. We investigate the impact… read more here.
Keywords: activity dopamine; dopamine receptor; constitutive activity; cav3 currents ... See more keywords
Targetable T-type Calcium Channels Drive Glioblastoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-2347
Abstract: Glioblastoma (GBM) stem-like cells (GSC) promote tumor initiation, progression, and therapeutic resistance. Here, we show how GSCs can be targeted by the FDA-approved drug mibefradil, which inhibits the T-type calcium channel Cav3.2. This calcium channel… read more here.
Keywords: glioblastoma; type calcium; mibefradil; cav3 ... See more keywords