Phosphorylation states greatly regulate the activity and gating properties of Cav3.1 T‐type Ca2+ channels
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DOI: 10.1002/jcp.30920
Abstract: Cav3.1 T‐type Ca2+ channels play pivotal roles in neuronal low‐threshold spikes, visceral pain, and pacemaker activity. Phosphorylation has been reported to potently regulate the activity and gating properties of Cav3.1 channels. However, systematic identification of… read more here.
Keywords: cav3 type; type ca2; activity; ca2 channels ... See more keywords
Cav3.2 T‐type calcium channel regulates mouse platelet activation and arterial thrombosis
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DOI: 10.1111/jth.15745
Abstract: Cav3.2 is a T‐type calcium channel that causes low‐threshold exocytosis. T‐type calcium channel blockers reduce platelet granule exocytosis and aggregation. However, studies of the T‐type calcium channel in platelets are lacking. read more here.
Keywords: type calcium; cav3 type; calcium channel;
Increased expression of CaV3.2 T-type calcium channels in damaged DRG neurons contributes to neuropathic pain in rats with spared nerve injury
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DOI: 10.1177/1744806918765808
Abstract: Ion channels are very important in the peripheral sensitization in neuropathic pain. Our present study aims to investigate the possible contribution of CaV3.2 T-type calcium channels in damaged dorsal root ganglion neurons in neuropathic pain.… read more here.
Keywords: calcium channels; type calcium; neuropathic pain; channels damaged ... See more keywords
Neuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity
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DOI: 10.7150/thno.62255
Abstract: Background: Neuromedin B (Nmb) is implicated in the regulation of nociception of sensory neurons. However, the underlying cellular and molecular mechanisms remain unknown. Methods: Using patch clamp recording, western blot analysis, immunofluorescent labelling, enzyme-linked immunosorbent… read more here.
Keywords: peripheral pain; neuromedin receptor; sensory neurons; hypersensitivity ... See more keywords