Exploring potential genes and pathways related to calcific aortic valve disease.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145987
Abstract: Calcific aortic valve disease (CAVD) is currently the most prevalent valvular disease. However, the pathological mechanism of CAVD has not yet been fully elucidated, and no drugs can delay or halt the progression of CAVD.… read more here.
Keywords: aortic valve; disease; calcific aortic; valve disease ... See more keywords
MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09390-z
Abstract: Calcific aortic valve disease (CAVD) is the most common heart valve disorder, yet its mechanism remains poorly understood. Valve interstitial cells (VICs) are the prevalent cells in aortic valve and their osteogenic differentiation may be… read more here.
Keywords: valve; mir 449c; osteogenic differentiation; cavd ... See more keywords
Multiomics identification of ALDH9A1 as a crucial immunoregulatory molecule involved in calcific aortic valve disease
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-75115-8
Abstract: Mitochondrial dysfunction and immune cell infiltration play crucial yet incompletely understood roles in the pathogenesis of calcific aortic valve disease (CAVD). This study aimed to identify immune-related mitochondrial genes critical to the pathological process of… read more here.
Keywords: mitochondrial genes; valve disease; aortic valve; calcific aortic ... See more keywords
Human antigen R regulates autophagic flux by stabilizing autophagy-associated mRNA in calcific aortic valve disease.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad077
Abstract: AIMS The incidence of calcific aortic valve disease (CAVD) has risen over the last decade and is expected to continue rising; however, pharmacological approaches have proven ineffective. In this study, we evaluated the role and… read more here.
Keywords: hur; aortic valve; human antigen; valve disease ... See more keywords
Molecular mechanisms involved in high glucose‐induced valve calcification in a 3D valve model with human valvular cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15277
Abstract: Calcific aortic valve disease (CAVD)—the most common valvular heart disease—is accelerated in diabetes and has no pharmacotherapy. Although it is known that early CAVD is associated with inflammation and osteogenesis, the molecular mechanisms involved in… read more here.
Keywords: calcification; high glucose; model; molecular mechanisms ... See more keywords
Overexpressed Thrombospondin 2 Induced Osteogenic Differentiation of Valve Interstitial Cells via Inhibition of Akt/NF-κB Signaling Pathway to Promote Calcific Aortic Valve Disease Development
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/2022958
Abstract: Thrombospondin 2 (THBS2) is reported to participate in the development of calcific aortic valve disease (CAVD), while the effects are not elucidated completely. The study aimed to explore the role and mechanism of THBS2 in… read more here.
Keywords: thbs2; development; valve; osteogenic differentiation ... See more keywords
Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.116.308761
Abstract: Objective— Lipoprotein(a) is causally associated with calcific aortic valve disease (CAVD). Lipoprotein(a) carries proinflammatory and procalcific oxidized phospholipids (OxPL). We tested whether the CAVD risk is mediated by the content of OxPL on lipoprotein(a). Approach… read more here.
Keywords: risk; oxpl apo; oxpl apob; lipoprotein ... See more keywords
Abstract 4142901: Identification of ANGPTL4 and ITGAV as Therapeutic Targets for Calcific Aortic Valve Disease through Comprehensive Mendelian Randomization Using Human Plasma Proteome
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4142901
Abstract: Background: Calcific aortic valve disease (CAVD) is a degenerative disease characterized by aortic valve fibrosis and calcification with no medications available for treatment. Multi-omics research is highly beneficial for identifying disease targets. In this study,… read more here.
Keywords: disease; aortic valve; mendelian randomization; cavd ... See more keywords
Abstract Wed119: Identification of Circulating miRNAs Linked to Endothelial ILK Deficiency: Novel Biomarkers for aortic valve calcific disease (CAVD) Monitoring
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.wed119
Abstract: Calcific aortic valve disease (CAVD) is the most common valvular heart disease worldwide, characterized by endothelial dysfunction, lipid accumulation, and inflammation, ultimately leading to calcification. We previously demonstrated that reduced integrin-linked kinase (ILK) expression in… read more here.
Keywords: endothelial ilk; disease; valve; aortic valve ... See more keywords
The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-024-04372-2
Abstract: The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential of the TG/HDL-C ratio to predict the… read more here.
Keywords: hdl ratio; density lipoprotein; high density; cavd ... See more keywords
Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0318574
Abstract: Objective Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative disease characterized by the accumulation of calcium deposits in the aortic valve. We aim to screen key genes associated with cellular senescence (CS) in… read more here.
Keywords: disease; cellular senescence; cavd; aortic valve ... See more keywords