Dysfunction of Caveolae‐Mediated Endocytic TβRI Degradation Results in Hypersensitivity of TGF‐β/Smad Signaling in Osteogenesis Imperfecta
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DOI: 10.1002/jbmr.4734
Abstract: Osteogenesis imperfecta (OI) is a genetic disorder caused by mutations of type I collagen‐related genes, and excessive transforming growth factor‐beta (TGF‐β) signaling is a common mechanism. TGF‐β/Smad signaling has inhibitory effects on osteoblast differentiation and… read more here.
Keywords: smad signaling; caveolae mediated; tgf smad; degradation ... See more keywords
PV1: Gatekeeper of Endothelial Permeability
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DOI: 10.1165/rcmb.2020-0294ed
Abstract: Endothelium is a monolayer of endothelial cells that lines the inner surface of blood vessels and plays a critical role in the maintenance of blood-vessel function and homeostasis. The endothelium is a semipermeable barrier that… read more here.
Keywords: endothelial permeability; permeability; caveolae mediated; transcytosis ... See more keywords
Functional characterization of nutraceuticals using spectral clustering: Centrality of caveolae-mediated endocytosis for management of nitric oxide and vitamin D deficiencies and atherosclerosis
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DOI: 10.3389/fnut.2022.885364
Abstract: It is well recognized that redox imbalance, nitric oxide (NO), and vitamin D deficiencies increase risk of cardiovascular, metabolic, and infectious diseases. However, clinical studies assessing efficacy of NO and vitamin D supplementation have failed… read more here.
Keywords: caveolae mediated; vitamin deficiencies; nitric oxide; spectral clustering ... See more keywords
Lymphocystis Disease Virus (Iridoviridae) Enters Flounder (Paralichthys olivaceus) Gill Cells via a Caveolae-Mediated Endocytosis Mechanism Facilitated by Viral Receptors
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DOI: 10.3390/ijms21134722
Abstract: In previous research, voltage-dependent anion channel protein 2 (VDAC2) and the receptor of activated protein C kinase 1 (RACK1) in flounder (Paralichthys olivaceus) were confirmed as functional receptors for lymphocystis disease virus (LCDV) entry; however,… read more here.
Keywords: rack1; caveolae mediated; endocytosis; mediated endocytosis ... See more keywords
Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis
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DOI: 10.3390/pharmaceutics13101557
Abstract: Human serum albumin (HSA) is efficiently taken up by cancer cells as a source of carbon and energy. In this study, we prepared a monomodified derivative of HSA covalently linked to an EDTA derivative and… read more here.
Keywords: anti proliferative; edta; caveolae mediated; mediated endocytosis ... See more keywords
Porcine Deltacoronavirus (PDCoV) Entry into PK-15 Cells by Caveolae-Mediated Endocytosis
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DOI: 10.3390/v14030496
Abstract: (1) Background: Porcine deltacoronavirus (PDCoV) is a newly emerged enteric virus affecting pig breeding industries worldwide, and its pathogenic mechanism remains unclear. (2) Methods: In this study, we preliminarily identified the endocytic pathway of PDCoV… read more here.
Keywords: caveolae mediated; mediated endocytosis; pdcov; pdcov entry ... See more keywords
Avian Reovirus σB Interacts with Caveolin-1 in Lipid Rafts during Dynamin-Dependent Caveolae-Mediated Endocytosis
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DOI: 10.3390/v14102201
Abstract: Caveolin-1 (Cav-1) is the basic component of caveolae, a specialized form of lipid raft that plays an essential role in endocytic viral entry. However, the evidence of direct involvement of caveolae and Cav-1 in avian… read more here.
Keywords: dynamin dependent; caveolae mediated; lipid rafts; avian reovirus ... See more keywords