Metformin alleviates high glucose-induced ER stress and inflammation by inhibiting the interaction between caveolin1 and AMPKα in rat astrocytes.
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DOI: 10.1016/j.bbrc.2020.10.075
Abstract: Hyperglycemia-induced endoplasmic reticulum (ER) stress and inflammatory response afflict neuropathological diseases (such as epilepsy and Alzheimer's disease). Astrocytes are the critical cells that mediate brain inflammation in this process. Metformin is a kind of hypoglycemic… read more here.
Keywords: high glucose; stress inflammation; caveolin1 ampk; inflammation ... See more keywords