Elucidating the role of Cavin1 in drug-induced long QT syndrome (diLQTS)
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DOI: 10.1093/eurheartj/ehab724.3315
Abstract: Several drugs can induce QT prolongation by altering cardiac ion currents, notably IKr. The cardiotoxic response to a drug is however extremely variable between individuals, ranging from no impact to life-threatening ventricular arrhythmias. The molecular… read more here.
Keywords: induced long; herg; sensitivity; drug ... See more keywords
Membrane insertion mechanism of the caveola coat protein Cavin1
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DOI: 10.1101/2021.03.23.436578
Abstract: Caveolae are small plasma membrane invaginations, important for control of membrane tension, signaling cascades and lipid sorting. The caveolae coat protein Cavin1 is essential for shaping such high curvature membrane structures. Yet, a mechanistic understanding… read more here.
Keywords: membrane; protein cavin1; cavin1; mechanism ... See more keywords