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   Articles with "cb1" as a keyword



Cannabinoid Type 1 Receptor (CB1) Ligands with Therapeutic Potential for Withdrawal Syndrome in Chemical Dependents of Cannabis sativa

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recommendations! Published in 2017 at "ChemMedChem"

DOI: 10.1002/cmdc.201700129

Abstract: Cannabis sativa withdrawal syndrome is characterized mainly by psychological symptoms. By using computational tools, the aim of this study was to propose drug candidates for treating withdrawal syndrome based on the natural ligands of the… read more here.

Keywords: cannabinoid type; type receptor; withdrawal syndrome; cannabis sativa ... See more keywords

Cell type specific impact of cannabinoid receptor signaling in somatosensory barrel map formation in mice

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recommendations! Published in 2019 at "Journal of Comparative Neurology"

DOI: 10.1002/cne.24733

Abstract: Endocannabinoids and their receptors are highly abundant in the developing cerebral cortex and play major roles in early developmental processes, for example, neuronal proliferation, migration, and axonal guidance as well as postnatal plasticity. To investigate… read more here.

Keywords: type specific; barrel; map; cb1 ... See more keywords

Central adiponectin induces trabecular bone mass partly through epigenetic downregulation of cannabinoid receptor CB1

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27460

Abstract: Central adiponectin (APN) in either the globular (gAPN) or full‐length forms decreases sympathetic tone and increases trabecular bone mass in mice through the hypothalamus. It is known that cannabinoid type‐1 (CB1) receptors are expressed in… read more here.

Keywords: central adiponectin; bone; expression; receptor ... See more keywords

Opposing roles of dorsomedial hypothalamic CB1 and TRPV1 receptors in anandamide signaling during the panic-like response elicited in mice by Brazilian rainbow Boidae snakes

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recommendations! Published in 2019 at "Psychopharmacology"

DOI: 10.1007/s00213-019-5170-2

Abstract: RationaleThe endocannabinoid system plays an important role in the organization of panic-like defensive behavior. Threatening situations stimulate brain areas, such as the dorsomedial hypothalamus (DMH). However, there is a lack of studies addressing the role… read more here.

Keywords: effect; dmh; trpv1 receptors; panic like ... See more keywords

Tart cherry (Prunus cerasus L.) dietary supplement modulates visceral adipose tissue CB1 mRNA levels along with other adipogenesis-related genes in rat models of diet-induced obesity

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recommendations! Published in 2021 at "European Journal of Nutrition"

DOI: 10.1007/s00394-020-02459-y

Abstract: Purpose There is increasing evidence for the involvement of dietary bioactive compounds in the cross-talk modulation of endocannabinoid system and some of the key regulators of transcriptional control for adipogenesis. Methods We aimed to characterize… read more here.

Keywords: tart cherry; visceral adipose; adipogenesis; adipose tissue ... See more keywords

Immunohistochemical localization of cannabinoid receptor 1 (CB1) in the submandibular gland of mice under normal conditions and when stimulated by isoproterenol or carbachol.

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recommendations! Published in 2017 at "Archives of oral biology"

DOI: 10.1016/j.archoralbio.2017.05.003

Abstract: OBJECTIVE We wished to investigate the subcellular localization of CB1, a receptor for the endocannabinoids in mouse submandibular glands (SMGs) under normal conditions and when stimulated by adrenergic or cholinergic agonists. MATERIALS AND METHODS SMGs… read more here.

Keywords: isoproterenol carbachol; ductal cells; normal conditions; cb1 ... See more keywords

5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to potential apoptotic antitumor agents.

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recommendations! Published in 2019 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2019.05.040

Abstract: Cannabinoids as THC and the CB1 allosteric modulator CBD were reported to have antiproliferative activities with no reports for other CB1 allosteric modulators as the 5-chloroindole-2-carboxamide derivatives and their furan congeners. Based on the antiproliferative… read more here.

Keywords: cell line; cb1 modulators; mcf cell; allosteric cb1 ... See more keywords
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Dissecting the role of CB1 and CB2 receptors in cannabinoid reward versus aversion using transgenic CB1- and CB2-knockout mice

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recommendations! Published in 2021 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2020.11.019

Abstract: Cannabinoids produce both rewarding and aversive effects in humans and experimental animals. However, the mechanisms underlying these conflicting findings are unclear. Here we examined the potential involvement of CB1 and CB2 receptors in cannabinoid action… read more here.

Keywords: cb2 receptors; mice; cb2; cb1 cb2 ... See more keywords

Targeted proteomics of cannabinoid receptor CB1 and the CB1b isoform

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recommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"

DOI: 10.1016/j.jpba.2016.11.003

Abstract: HIGHLIGHTSSRM‐MS method for the identification and differentiation of CB1 and CB1b.Application of the method to CHO cells transduced with CB1 or CB1b. ABSTRACT Cannabinoid receptors (CBR), including CB1 and CB2 have been therapeutic targets for… read more here.

Keywords: receptor; cb1; cb1 cb1b; cb1b isoform ... See more keywords

Chronic aerobic exercise: Lack of effect on brain CB1 receptor levels in adult rats.

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recommendations! Published in 2019 at "Life sciences"

DOI: 10.1016/j.lfs.2019.05.058

Abstract: INTRODUCTION Exercise programs have been shown to be effective for both reducing risk for, and intervention following, substance abuse behaviors in both clinical and preclinical studies. Less is known, however, regarding the underlying neurobiological substrates… read more here.

Keywords: cb1; chronic aerobic; receptor; aerobic exercise ... See more keywords

Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat

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recommendations! Published in 2022 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2021.108935

Abstract: AIMS Acetaminophen or paracetamol (PAR), the recommended antipyretic in COVID-19 and clinically used to alleviate stroke-associated hyperthermia interestingly activates cannabinoid receptor (CB1) through its AM404 metabolite, however, to date, no study reports the in vivo… read more here.

Keywords: cb1; pi3k akt; par; reperfusion ... See more keywords