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Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700129
Abstract: Cannabis sativa withdrawal syndrome is characterized mainly by psychological symptoms. By using computational tools, the aim of this study was to propose drug candidates for treating withdrawal syndrome based on the natural ligands of the…
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Keywords:
cannabinoid type;
type receptor;
withdrawal syndrome;
cannabis sativa ... See more keywords
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Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24733
Abstract: Endocannabinoids and their receptors are highly abundant in the developing cerebral cortex and play major roles in early developmental processes, for example, neuronal proliferation, migration, and axonal guidance as well as postnatal plasticity. To investigate…
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Keywords:
type specific;
barrel;
map;
cb1 ... See more keywords
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Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27460
Abstract: Central adiponectin (APN) in either the globular (gAPN) or full‐length forms decreases sympathetic tone and increases trabecular bone mass in mice through the hypothalamus. It is known that cannabinoid type‐1 (CB1) receptors are expressed in…
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Keywords:
central adiponectin;
bone;
expression;
receptor ... See more keywords
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Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-5170-2
Abstract: RationaleThe endocannabinoid system plays an important role in the organization of panic-like defensive behavior. Threatening situations stimulate brain areas, such as the dorsomedial hypothalamus (DMH). However, there is a lack of studies addressing the role…
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Keywords:
effect;
dmh;
trpv1 receptors;
panic like ... See more keywords
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Published in 2021 at "European Journal of Nutrition"
DOI: 10.1007/s00394-020-02459-y
Abstract: Purpose There is increasing evidence for the involvement of dietary bioactive compounds in the cross-talk modulation of endocannabinoid system and some of the key regulators of transcriptional control for adipogenesis. Methods We aimed to characterize…
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Keywords:
tart cherry;
visceral adipose;
adipogenesis;
adipose tissue ... See more keywords
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Published in 2017 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.05.003
Abstract: OBJECTIVE We wished to investigate the subcellular localization of CB1, a receptor for the endocannabinoids in mouse submandibular glands (SMGs) under normal conditions and when stimulated by adrenergic or cholinergic agonists. MATERIALS AND METHODS SMGs…
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Keywords:
isoproterenol carbachol;
ductal cells;
normal conditions;
cb1 ... See more keywords
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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.05.040
Abstract: Cannabinoids as THC and the CB1 allosteric modulator CBD were reported to have antiproliferative activities with no reports for other CB1 allosteric modulators as the 5-chloroindole-2-carboxamide derivatives and their furan congeners. Based on the antiproliferative…
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Keywords:
cell line;
cb1 modulators;
mcf cell;
allosteric cb1 ... See more keywords
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Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2020.11.019
Abstract: Cannabinoids produce both rewarding and aversive effects in humans and experimental animals. However, the mechanisms underlying these conflicting findings are unclear. Here we examined the potential involvement of CB1 and CB2 receptors in cannabinoid action…
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Keywords:
cb2 receptors;
mice;
cb2;
cb1 cb2 ... See more keywords
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Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.11.003
Abstract: HIGHLIGHTSSRM‐MS method for the identification and differentiation of CB1 and CB1b.Application of the method to CHO cells transduced with CB1 or CB1b. ABSTRACT Cannabinoid receptors (CBR), including CB1 and CB2 have been therapeutic targets for…
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Keywords:
receptor;
cb1;
cb1 cb1b;
cb1b isoform ... See more keywords
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Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.05.058
Abstract: INTRODUCTION Exercise programs have been shown to be effective for both reducing risk for, and intervention following, substance abuse behaviors in both clinical and preclinical studies. Less is known, however, regarding the underlying neurobiological substrates…
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Keywords:
cb1;
chronic aerobic;
receptor;
aerobic exercise ... See more keywords
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Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108935
Abstract: AIMS Acetaminophen or paracetamol (PAR), the recommended antipyretic in COVID-19 and clinically used to alleviate stroke-associated hyperthermia interestingly activates cannabinoid receptor (CB1) through its AM404 metabolite, however, to date, no study reports the in vivo…
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Keywords:
cb1;
pi3k akt;
par;
reperfusion ... See more keywords