Application of an activity-based receptor bioassay to investigate the in vitro activity of selected indole- and indazole-3-carboxamide-based synthetic cannabinoids at CB1 and CB2 receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2517
Abstract: Synthetic cannabinoids (SCs) are the most chemically diverse group of new psychoactive substances. This group has been associated with several intoxications, many with fatal outcomes. Although advancements have been achieved in pharmacology, metabolism, and detection… read more here.
Keywords: synthetic cannabinoids; indole indazole; cb1 cb2; investigate vitro ... See more keywords
Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates
Sign Up to like & getrecommendations! Published in 2020 at "Brain Structure and Function"
DOI: 10.1007/s00429-020-02116-4
Abstract: Endocannabinoids are neuromodulators acting on specific cannabinoid CB1 and CB2 G-protein-coupled receptors (GPCRs), representing potential therapeutic targets for neurodegenerative diseases. Cannabinoids also regulate the activity of GPR55, a recently “deorphanized” GPCR that directly interacts with… read more here.
Keywords: gpr55; control; expression; cb2 ... See more keywords
Evaluation of carboxamide-type synthetic cannabinoids on the functional activities at cannabinoid receptors and biological effects via inhalation exposure test
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DOI: 10.1007/s11419-020-00534-x
Abstract: Three synthetic carboxamide-type cannabinoids (5F-MDMB-PICA, 5F-EMB-PINACA, and AMB-CHMICA) were evaluated in terms of their in vitro activities at the cannabinoid receptors CB1 and CB2 and in vivo biological effects when smoking the synthetic cannabinoids to… read more here.
Keywords: carboxamide type; synthetic cannabinoids; mdmb pica; activities cannabinoid ... See more keywords
Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1‐CB2 heteroreceptor complexes
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.08.046
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Currently, biased agonism is at the center stage of drug development approaches. We analyzed effects of a battery of cannabinoids plus/minus cannabidiol (CBD) in four functional parameters (cAMP… read more here.
Keywords: effect; cb1 cb2; biased agonism;
The endocannabinoid 2‐arachidonoylglycerol regulates oligodendrocyte progenitor cell migration
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.09.006
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT While the endocannabinoid 2‐arachidonoylglycerol (2‐AG) is thought to enhance the proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) in vitro, less is known about how endogenous 2‐AG may… read more here.
Keywords: migration; oligodendrocyte progenitor; cb1 cb2; endocannabinoid arachidonoylglycerol ... See more keywords
Dissecting the role of CB1 and CB2 receptors in cannabinoid reward versus aversion using transgenic CB1- and CB2-knockout mice
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2020.11.019
Abstract: Cannabinoids produce both rewarding and aversive effects in humans and experimental animals. However, the mechanisms underlying these conflicting findings are unclear. Here we examined the potential involvement of CB1 and CB2 receptors in cannabinoid action… read more here.
Keywords: cb2 receptors; mice; cb2; cb1 cb2 ... See more keywords
Human bone marrow mesenchymal stem cells secrete endocannabinoids that stimulate in vitro hematopoietic stem cell migration effectively comparable to beta-adrenergic stimulation.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental hematology"
DOI: 10.1016/j.exphem.2017.09.009
Abstract: Granulocyte colony-stimulating factor (G-CSF) is a well-known hematopoietic stem cell (HSC)-mobilizing agent used in both allogeneic and autologous transplantation. However, a proportion of patients or healthy donors fail to mobilize a sufficient number of cells.… read more here.
Keywords: cb1 cb2; csf; stem cell; migration ... See more keywords
Surprising outcomes in cannabinoid CB1/CB2 receptor double knockout mice in two models of ischemia
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DOI: 10.1016/j.lfs.2017.12.030
Abstract: Aims: We tested the hypothesis that CB1/CB2 receptor double knockout would produce significant increases in infarct size and volume and significant worsening in clinical score, using two mouse models, one of permanent ischemia and one… read more here.
Keywords: knockout mice; double knockout; receptor; cb1 cb2 ... See more keywords
Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases
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DOI: 10.1038/s41392-020-00240-5
Abstract: Cannabinoids (CBs), analgesic drugs used for thousands of years, were first found in Cannabis sativa, and the multiple CBs used medicinally, such as tetrahydrocannabinol (THC), cannabidiol (CBD) and dozens more, have complex structures. In addition… read more here.
Keywords: drug; cb2; structure; receptor ... See more keywords
Imaging Cannabinoid Receptors: A Brief Collection of Covalent and Fluorescent Probes for CB1 and CB2 Receptors
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DOI: 10.1071/ch21007
Abstract: There has been an expanding public interest towards the notion that modulation of the sophisticated endocannabinoid system can lead to various therapeutic benefits that are yet to be fully explored. In recent years, the drug… read more here.
Keywords: fluorescent; cannabinoid receptors; imaging cannabinoid; cb1 cb2 ... See more keywords
Absence of Entourage: Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors
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DOI: 10.1089/can.2019.0016
Abstract: Abstract Introduction: Compounds present in Cannabis sativa such as phytocannabinoids and terpenoids may act in concert to elicit therapeutic effects. Cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) directly activate cannabinoid receptor 1 (CB1) and cannabinoid receptor 2… read more here.
Keywords: cb1 cb2; cb1; cannabinoid receptor; cannabis sativa ... See more keywords