CB1 Receptor Antagonist Selonabant (ANEB‐001) Blocks Acute THC Effects in Healthy Volunteers: A Phase II Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3581
Abstract: Emergency department visits due to cannabinoid‐induced toxicity, including acute cannabinoid intoxication (ACI) have increased worldwide as more states have liberalized cannabis policy. ACI symptoms include anxiety, panic attacks, tachycardia, and psychosis, primarily mediated through cannabinoid… read more here.
Keywords: receptor; cb1 receptor; thc; receptor antagonist ... See more keywords
Solid-phase synthesis of imprinted nanoparticles as artificial antibodies against the C-terminus of the cannabinoid CB1 receptor: exploring a viable alternative for bioanalysis
Sign Up to like & getrecommendations! Published in 2021 at "Mikrochimica Acta"
DOI: 10.1007/s00604-021-05029-z
Abstract: The production of artificial anti-CB1 antibodies in nanoparticle format is described using the solid-phase imprinting approach. Instead of whole protein imprinting, a linear C-terminus sequence of the receptor comprising 15 amino acids (458-KVTMSVSTDTSAEAL-472) has been… read more here.
Keywords: receptor; phase synthesis; cb1 receptor; solid phase ... See more keywords
Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2591-y
Abstract: Depression is a common mental disorder in adolescents, with a prevalence rate of 5.6%. Current anti-depressive options for adolescents are limited: psychological intervention and conventional antidepressants have low efficacy, a delayed onset of action and… read more here.
Keywords: depression; cb1 receptor; like behaviors; depressive like ... See more keywords
PPAR&agr;/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: Evaluation of a novel oleic acid conjugate in preclinical rat models
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.09.008
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Recent studies have demonstrated the utility of drugs modulating the endogenous cannabinoid system to control excessive alcohol intake. Among them, drugs interacting with acylethanolamide receptors including cannabinoid CB1… read more here.
Keywords: ppar agr; cb1 receptor; receptor; dual ligands ... See more keywords
Metabolic side effects induced by olanzapine treatment are neutralized by CB1 receptor antagonist compounds co-administration in female rats
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.03.010
Abstract: Weight gain is an important side effect of most atypical antipsychotic drugs such as olanzapine. Moreover, although many animal models with metabolic side effects have been well defined, the interaction with other pathways has to… read more here.
Keywords: metabolic side; treatment; weight gain; cb1 receptor ... See more keywords
Cocaine-induced increases in motivation require 2-arachidonoylglycerol mobilization and CB1 receptor activation in the ventral tegmental area
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108625
Abstract: A wide body of evidence supports an integral role for mesolimbic dopamine (DA) in motivated behavior. In brief, drugs that increase DA in mesolimbic terminal regions, like cocaine, enhance motivation, while drugs that decrease DA… read more here.
Keywords: cb1 receptor; cocaine induced; activation; cocaine ... See more keywords
Chloramphenicol decreases CB1 receptor expression in the nucleus accumbens and prefrontal cortex and prevents amphetamine-induced conditioned place preference in rats
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2017.06.008
Abstract: Abstract Drug dependence seems to involve a learning and memory process. Since learning and memory depend on protein synthesis, drug dependence may depend on protein synthesis, too. Drug‐induced reward is a crucial effect for the… read more here.
Keywords: conditioned place; cb1 receptor; place preference; group ... See more keywords
In vivo evaluation of the CB1 allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2019.172840
Abstract: In the present study, we examined whether LDK1258, which produces strong CB1 receptor allosteric effects in in vitro assays, would elicit in vivo effects consistent with allosteric activity. In initial studies, LDK1258 reduced food consumption… read more here.
Keywords: cb1 receptor; receptor allosteric; effects vivo; receptor ... See more keywords
Remote CB1 receptor antagonist administration reveals multiple sites of tonic and phasic endocannabinoid neuroendocrine regulation
Sign Up to like & getrecommendations! Published in 2020 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2019.104549
Abstract: Endogenous cannabinoids (endocannabinoids, eCB) are expressed throughout the body and contribute to regulation of the hypothalamo-pituitary-adrenal (HPA) axis and general stress reactivity. This study assessed the contributions of CB1 receptors (CB1R) in the modulation of… read more here.
Keywords: cb1r; cb1 receptor; remote cb1; hpa axis ... See more keywords
Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01052
Abstract: The biosynthetic and catabolic enzymes of the endocannabinoids tightly regulate endocannabinoid-mediated activation of the cannabinoid CB1 receptor. Monitoring the activities of these endocannabinoid hydrolases in different brain regions is, therefore, key to gaining insight into… read more here.
Keywords: brain; activity; cb1 receptor; endocannabinoid hydrolases ... See more keywords
Development of a Cell Membrane Conformational Cannabinoid CB1 Receptor Biosensor for the Detection of Synthetic Cannabinoids.
Sign Up to like & getrecommendations! Published in 2025 at "ACS sensors"
DOI: 10.1021/acssensors.4c03589
Abstract: This study aimed to develop a chemical structure-independent, sensitive screening platform for detecting novel synthetic cannabinoids using isolated cell membranes. Resonance energy transfer techniques were employed to detect conformational changes in the CB1 receptor upon… read more here.
Keywords: detection synthetic; cb1 receptor; cannabinoid cb1; cell ... See more keywords