Biased Coupling to β-Arrestin of Two Common Variants of the CB2 Cannabinoid Receptor
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.714561
Abstract: β-arrestins are partners of the G protein-coupled receptors (GPCRs), regulating their intracellular trafficking and signaling. Development of biased GPCR agonists, selectively targeting either G protein or β-arrestin pathways, are in the focus of interest due… read more here.
Keywords: cb2 cannabinoid; common variants; two common; variants cb2 ... See more keywords
CB2 cannabinoid receptor expression is increased in 129S1/SvImJ mice: behavioral consequences
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.975020
Abstract: Genetic and environmental factors are implicated in the etiology of neuropsychiatric diseases. Inbred mouse strains, including the 129S1/SvImJ (S1), constitute important models to study the influence of genetic factors in these conditions. S1 mice displayed… read more here.
Keywords: cb2 cannabinoid; expression; cannabinoid receptor; 129s1 svimj ... See more keywords
New Insights and Potential Therapeutic Targeting of CB2 Cannabinoid Receptors in CNS Disorders
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DOI: 10.3390/ijms23020975
Abstract: The endocannabinoid system (ECS) is ubiquitous in most human tissues, and involved in the regulation of mental health. Consequently, its dysregulation is associated with neuropsychiatric and neurodegenerative disorders. Together, the ECS and the expanded endocannabinoidome… read more here.
Keywords: cns disorders; cannabinoid receptors; cb2 cannabinoid; potential therapeutic ... See more keywords
Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors
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DOI: 10.3390/life12050624
Abstract: Molecular docking revealed curcumin as a potent CB2 cannabinoid receptor (CB2R) agonist. Since CB2R is involved in cardioprotective functions, we explored its role in ameliorative actions of curcumin against myocardial damage triggered by isoproterenol in… read more here.
Keywords: cb2 cannabinoid; day; diabetic mice; myocardial infarction ... See more keywords