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Published in 2019 at "Synapse"
DOI: 10.1002/syn.22139
Abstract: CB2 receptors (CB2R) are expressed in midbrain neurons. To evidence the control of dopamine release in dorsal striatum by CB2R, we performed experiments of [3H]‐dopamine release in dorsal striatal slices. We found a paradoxical increase…
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Keywords:
dopamine release;
effect;
cb2r;
autoreceptor switches ... See more keywords
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Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-022-00565-9
Abstract: Diabetes mellitus promotes accelerated cardiovascular aging and inflammation, which in turn facilitate the development of cardiomyopathy/heart failure. High glucose-induced oxidative/nitrative stress, activation of various pro-inflammatory, and cell death pathways are critical in the initiation and…
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Keywords:
activation;
fibrosis;
diabetes induced;
stress ... See more keywords
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Published in 2018 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2018.11.013
Abstract: BACKGROUND The role of CB2R gene variants on weight loss after a dietary intervention has been investigated in few studies. OBJECTIVE We evaluate the effect of this genetic variant (rs3123554) of CB2R gene on cardiovascular…
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Keywords:
non allele;
hypocaloric diets;
different hypocaloric;
allele carriers ... See more keywords
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Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.03.040
Abstract: Background We have recently reported that activation of cannabinoid type 2 receptors (CB2Rs) reduces dopamine (DA) neuron excitability in mouse ventral tegmental area (VTA). Here, we elucidate the underlying mechanisms. Methods Patch-clamp recordings were performed…
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Keywords:
vta;
reduction;
excitability mouse;
jwh133 ... See more keywords
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1
Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114138
Abstract: The development of neurodegenerative diseases is associated with cerebral inflammation, which activates resident immune cells of the central nervous system (CNS), namely microglial cells that show an up-regulation of the cannabinoid subtype 2 receptor (CB2R)…
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Keywords:
cannabinoid subtype;
development;
cb2r;
tracer ... See more keywords
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Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01357
Abstract: The cannabinoid receptor subtype 2 (CB2R) represents an interesting and new therapeutic target for its involvement in the first steps of neurodegeneration as well as in cancer onset and progression. Several studies, focused on different…
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Keywords:
subtype cb2r;
cannabinoid receptor;
cb2r;
receptor subtype ... See more keywords
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Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00746
Abstract: Upregulation of the cannabinoid type 2 receptors (CB2R) unveils inflammation processes of pathological disorders, such as cancer, pain, or neurodegenerative diseases. Among others, CB2R agonist A-836339 has been labeled with carbon-11 for PET imaging of…
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Keywords:
cannabinoid;
cb2r;
pet imaging;
structure activity ... See more keywords
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Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-96285-9
Abstract: Although the cannabinoid receptor 2 (CB2R) is often thought to play a role mainly outside the brain several publications unequivocally showed the presence of CB2R on hippocampal principal neurons. Activation of CB2R produced a long-lasting…
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Keywords:
social memory;
cannabinoid receptor;
synaptic architecture;
cb2r ... See more keywords
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Published in 2017 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjx096
Abstract: Background and Aims Cannabinoid receptor stimulation may have positive symptomatic effects on inflammatory bowel disease [IBD] patients through analgesic and anti-inflammatory effects. The cannabinoid 2 receptor [CB2R] is expressed primarily on immune cells, including CD4+…
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Keywords:
disease;
tnf mice;
cannabinoid receptor;
model ... See more keywords
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Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0913-7
Abstract: BackgroundNeuroinflammation plays a major role in postoperative cognitive dysfunction (POCD). Accumulated evidence indicates that cannabinoid receptor type 2 (CB2R) can mediate anti-inflammatory and immunomodulatory effects in part by controlling microglial activity. However, the impact of…
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Keywords:
surgery;
surgery induced;
mice;
cb2r ... See more keywords
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1
Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.993168
Abstract: Background Neuroinflammation following spinal cord injury (SCI) results in prolonged neurological damage and locomotor dysfunction. Polarization of microglia is vital to regulation of neuroinflammation, although the underlying mechanisms have not yet been elucidated. Endocannabinoid receptor…
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Keywords:
cord injury;
neuroinflammation;
spinal cord;
cb2r ... See more keywords