CBASS phage defense and evolution of antiviral nucleotide signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2022.01.002
Abstract: Cyclic oligonucleotide-based antiphage signaling system (CBASS) immunity is a widespread form of antiphage defense in bacteria and archaea. Each CBASS operon encodes a cGAS/DncV-like Nucleotidyltransferase (CD-NTase) enzyme that synthesizes a nucleotide second messenger in response… read more here.
Keywords: cbass; defense; phage defense; evolution ... See more keywords
Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.12.010
Abstract: Bacteria possess an array of defenses against foreign invaders, including a broadly distributed bacteriophage defense system termed CBASS (cyclic oligonucleotide-based anti-phage signaling system). In CBASS systems, a cGAS/DncV-like nucleotidyltransferase synthesizes cyclic di- or tri-nucleotide second… read more here.
Keywords: structure mechanism; mechanism cyclic; bacteriophage immunity; bacteriophage ... See more keywords
Control of bacterial immune signaling by a WYL domain transcription factor
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac343
Abstract: Bacteria use diverse immune systems to defend themselves from ubiquitous viruses termed bacteriophages (phages). Many anti-phage systems function by abortive infection to kill a phage-infected cell, raising the question of how they are regulated to… read more here.
Keywords: immune; phage; transcription factor; cbass ... See more keywords