Abstract A124: CBB-120: A TROP2-targeted dual-payload ADC combining Top1i and ATRi mechanisms demonstrates superior efficacy in preclinical models and improved safety in non-human primates
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DOI: 10.1158/1535-7163.targ-25-a124
Abstract: Antibody-drug conjugates (ADCs) have emerged as a powerful strategy for treating TROP2-expressing epithelial cancers, including breast and lung cancers. Among current therapies, Trodelvy® and Datroway® (Dato-DXd) carrying topoisomerase I inhibitors (Top1i) have demonstrated notable clinical… read more here.
Keywords: cbb 120; payload adc; trop2; top1i atri ... See more keywords