Cannabidiol‐Loaded Poly Lactic‐Co‐Glycolic Acid Nanoparticles with Improved Bioavailability as a Potential for Osteoarthritis Therapeutic
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200698
Abstract: Cannabidiol (CBD) is a non‐intoxicating cannabinoid from cannabis sativa that has demonstrated efficacious against inflammation, which can be considered as a potential drug for arthritis treatment. However, the poor solubility and low bioavailability limit its… read more here.
Keywords: cbd plga; cannabidiol; bioavailability; plga nps ... See more keywords
Single‐Dose Pharmacokinetics of Oral Cannabidiol Following Administration of PTL101: A New Formulation Based on Gelatin Matrix Pellets Technology
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.408
Abstract: Cannabidiol (CBD) is the main nonpsychoactive component of the cannabis plant. It has been associated with antiseizure, antioxidant, neuroprotective, anxiolytic, anti‐inflammatory, antidepressant, and antipsychotic effects. PTL101 is an oral gelatin matrix pellets technology–based formulation containing… read more here.
Keywords: cbd; pellets technology; matrix pellets; formulation ... See more keywords
Detection of Δ9 THC in oral fluid following vaporized cannabis with varied cannabidiol (CBD) content: An evaluation of two point‐of‐collection testing devices
Sign Up to like & getrecommendations! Published in 2019 at "Drug Testing and Analysis"
DOI: 10.1002/dta.2687
Abstract: Abstract Point‐of‐collection testing (POCT) for Δ9‐tetrahydrocannabinol (THC) in oral fluid is increasingly used to detect driving under the influence of cannabis (DUIC). However, previous studies have questioned the reliability and accuracy of two commonly used… read more here.
Keywords: oral fluid; cbd; point collection; thc cbd ... See more keywords
Analysis of illicit drugs in purchased and seized electronic cigarette liquids from the UK 2014-2021.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3277
Abstract: Increasing popularity and known shortfalls in the regulation of electronic cigarettes (ECs) emphasises the urgent need for closer content monitoring and for comprehensible information on their possible health effects. This study investigated components of EC… read more here.
Keywords: thc; analysis illicit; illicit drugs; 2014 2021 ... See more keywords
How long does a single oral dose of cannabidiol persist in plasma? Findings from three clinical trials.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3419
Abstract: A growing number of clinical trials (CTs) are investigating the therapeutic potential of cannabidiol (CBD), a non-intoxicating phytocannabinoid found in Cannabis sativa. These CTs often use crossover experimental designs requiring 'washout' (clearance) periods. However, the… read more here.
Keywords: clinical trials; persist plasma; cbd; single oral ... See more keywords
Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6831
Abstract: Fish oil (FO) and phytocannabinoids have received considerable attention for their intestinal anti‐inflammatory effects. We investigated whether the combination of FO with cannabigerol (CBG) and cannabidiol (CBD) or a combination of all three treatments results… read more here.
Keywords: cbd; oil phytocannabinoids; inflammation; cbg ... See more keywords
Engineered Nucleotide Chemicapacitive Microsensor Array Augmented with Physics-Guided Machine Learning for High-Throughput Screening of Cannabidiol.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202107659
Abstract: The recent legalization of cannabidiol (CBD) to treat neurological conditions such as epilepsy has sparked rising interest across global pharmaceuticals and synthetic biology industries to engineer microbes for sustainable synthetic production of medicinal CBD. Since… read more here.
Keywords: physics; cannabidiol; high throughput; physics guided ... See more keywords
A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR‐1 mediated mitochondrial dysfunction and apoptosis
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23752
Abstract: Cannabidiol (CBD) is a nonpsychoactive cannabinoid compound. It has been shown that CBD can inhibit the proliferation of ovarian cancer cells, but the underlying specific mechanism is unclear. We previously presented the first evidence for… read more here.
Keywords: lair; cancer cells; cbd; ovarian cancer ... See more keywords
Cannabidiol modulation of antinociceptive tolerance to Δ9-tetrahydrocannabinol
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5036-z
Abstract: RationaleHumans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance… read more here.
Keywords: cbd; tolerance; vehicle; tetrahydrocannabinol ... See more keywords
Cannabidiol: pharmacology and therapeutic targets
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05712-8
Abstract: Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-treat a myriad of conditions and for their unsubstantiated health benefits. The scientific evidence supporting these claims largely arises not from controlled clinical trials,… read more here.
Keywords: cbd; therapeutic targets; cannabidiol pharmacology; pharmacology therapeutic ... See more keywords
Trans-infundibular choledochoscopy: a method for accessing the common bile duct in complex cases
Sign Up to like & getrecommendations! Published in 2018 at "Langenbeck's Archives of Surgery"
DOI: 10.1007/s00423-018-1698-6
Abstract: PurposeDuring laparoscopic common bile duct exploration (LCBDE) where Calot’s triangle cannot be safely dissected due to a ‘frozen’ hepatic hilum secondary to severe inflammation or fibrosis, the preferred transcystic approach to the common bile duct… read more here.
Keywords: common bile; cbd; trans infundibular; bile duct ... See more keywords