Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation.
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DOI: 10.1021/acsmedchemlett.3c00461
Abstract: Cannabidiol (CBD 1) is a nonpsychotic cannabinoid-based drug approved by the U.S. FDA for treating refractory epilepsy, namely, Lennox-Gastaut and Dravet syndrome. However, its low aqueous solubility and oral bioavailability are compensated by administering high… read more here.
Keywords: synthesis bioevaluation; cannabidiol based; cbd based; based prodrugs ... See more keywords
Design, Synthesis, and Evaluation of Antinociceptive Properties of Novel CBD-Based Terpene-Cinnamoyl-Acyl-Hydrazone Analogues
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DOI: 10.3390/ph18050755
Abstract: Background/Objectives: Cannabidiol (CBD) has been reported for its antinociceptive, anti-inflammatory, and neuroprotective activities. However, several legal restrictions on its medicinal uses and even research have contributed to the development of synthetic analogues. Therefore, the aim… read more here.
Keywords: cbd based; pqm; acyl hydrazone; terpene cinnamoyl ... See more keywords