The effects of CBD and THC in animal models of depression and anxiety
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2019.03.023
Abstract: Objectives Epilepsy patients frequently suffer from psychiatric comorbidities, such as depression and anxiety, which seriously affect their quality of life. CBD has been reported to have not only anti-seizure effects, but also to have possible… read more here.
Keywords: thc; animal models; depression anxiety; cbd thc ... See more keywords
Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol
Sign Up to like & getrecommendations! Published in 2023 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.3c00017
Abstract: The cannabinoids cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) undergo extensive oxidative metabolism in the liver. Although cytochromes P450 form the primary, pharmacologically active, hydroxylated metabolites of CBD and THC, less is known about the enzymes that… read more here.
Keywords: metabolites cbd; carboxy cbd; carboxy thc; cbd thc ... See more keywords
Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21218035
Abstract: The anti-cancer effects of cannabinoids including CBD (Cannabidiol) and THC ((−)-trans-∆9-tetrahydrocannabinol) have been reported in the case of pancreatic cancer (PC). The connection of these cannabinoids to KRas oncogenes that mutate in more than 90%… read more here.
Keywords: cancer; pancreatic cancer; cbd thc; activated kinase ... See more keywords