Single base substitution and insertion/deletion mutational signatures in adult core binding factor acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Leukemia"
DOI: 10.1038/s41375-022-01552-x
Abstract: TO THE EDITOR Single base substitutions (SBSs) and insertions/deletions (indels; IDs) arise through several mechanisms such as errors during DNA replication/repair and exposures to mutagens, with the different mutational processes occasionally generating specific mutational signatures.… read more here.
Keywords: cancer; runx1 runx1t1; aml; mutational signatures ... See more keywords
Myeloid Sarcoma With CBFB-MYH11 Fusion (inv(16) or t(16;16)) Prevails in the Abdomen.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqz168
Abstract: OBJECTIVES Myeloid sarcoma with CBFB-MYH11 fusion may be enriched in abdominal sites. The clinicopathologic features of 11 cases are reported. METHODS We collected clinical features, morphology, immunophenotype, and bone marrow (BM) involvement of myeloid sarcoma… read more here.
Keywords: myh11 fusion; myeloid sarcoma; sarcoma cbfb; cbfb myh11 ... See more keywords
Cryptic insertion of CBFB into MYH11 leading to a type D fusion in acute myeloid leukemia with normal karyotype
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13694
Abstract: Dear Editors, Acute myeloid leukemia (AML) with inv(16)(p13q22)/t(16;16) (p13;q22) has distinct clinicopathologic features, including myelomonocytic leukemic cells, abnormal bone marrow eosinophils, and a relatively favorable prognosis.1,2 Most cases are classified as AML M4 with abnormal… read more here.
Keywords: acute myeloid; fusion; myh11; insertion ... See more keywords
CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.675424
Abstract: A growing number of human diseases have been found to be associated with aberrant DNA methylation, including cancer. Mutations targeting genes encoding DNA methyltransferase (DNMT), TET family of DNA demethylases, and isocitrate dehydrogenase (IDH1, IDH2)… read more here.
Keywords: myh11 fusion; target genes; cbfb myh11; myh11 ... See more keywords