Identification of Cannabidiolic and Cannabigerolic Acids as MTDL AChE, BuChE, and BACE‐1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies
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DOI: 10.1002/ptr.8369
Abstract: Cannabidiolic (CBDA) and cannabigerolic (CBGA) acids are naturally occurring compounds from Cannabis sativa plant, previously identified by us as dual PPARα/γ agonists. Since the development of multitarget‐directed ligands (MTDL) represents a valuable strategy to alleviate… read more here.
Keywords: cbga; ache buche; bace; cbda cbga ... See more keywords
CBGA-ES+: A Cluster-Based Genetic Algorithm with Non-Dominated Elitist Selection for Supporting Multi-Objective Test Optimization
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DOI: 10.1109/tse.2018.2882176
Abstract: Many real-world test optimization problems (e.g., test case prioritization) are multi-objective intrinsically and can be tackled using various multi-objective search algorithms (e.g., Non-dominated Sorting Genetic Algorithm (NSGA-II)). However, existing multi-objective search algorithms have certain randomness… read more here.
Keywords: genetic algorithm; cbga; test optimization; multi objective ... See more keywords
Implications of the effects of cannabigerolic acid on our understanding of the potential of phytocannabinoids in anti‐seizure treatment
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DOI: 10.1111/bph.15740
Abstract: Before widespread prohibition, cannabis and cannabis products had been used in the treatment of epilepsy and seizures with evidence for use stretching back millennia. In recent years, there has been growing evidence that cannabis products… read more here.
Keywords: anti seizure; epilepsy; treatment; cbga ... See more keywords