Tissue distribution of oral vitamin B12 is influenced by B12 status and B12 form: an experimental study in rats
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nutrition"
DOI: 10.1007/s00394-017-1424-0
Abstract: PurposeHydroxocobalamin (HOCbl) is the dominating Cbl form in food, whereas cyanocobalamin (CNCbl) is common in vitamin pills and oral supplements. This study compares single-dose absorption and distribution of oral HO[57Co]Cbl and CN[57Co]Cbl in Cbl-deficient and… read more here.
Keywords: distribution oral; cbl; 57co cbl; form ... See more keywords
Nanodelivery of Cerebrolysin and Rearing in Enriched Environment Induce Neuroprotective Effects in a Preclinical Rat Model of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0741-x
Abstract: Rearing in enriched environment (EE) improves the recuperation in animal models of Parkinson’s disease (PD). Administration of TiO2-nanowired cerebrolysin (CBL) could represent an additional strategy to protect or repair the nigrostriatal system. This study aims… read more here.
Keywords: cbl; enriched environment; rearing enriched; group ... See more keywords
A novel, germline, deactivating CBL variant p.L493F alters domain orientation and is associated with multiple childhood cancers.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2021.01.008
Abstract: CBL is a mammalian gene encoding the protein CBL, which is an E3 ubiquitin-protein ligase involved in cell signaling and protein ubiquitination. Pathogenic variants in this gene have been implicated in a number of human… read more here.
Keywords: cbl; germline deactivating; deactivating cbl; cbl variant ... See more keywords
C-Cbl and Cbl-b expression in skull base chordomas is associated with tumor progression and poor prognosis.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2017.12.019
Abstract: Chordomas are rare, locally aggressive malignancies that are often difficult to eradicate. Surgery and radiotherapy are the first-line treatments, but the probability of local recurrence is high. According to our previous research, c-Cbl and Cbl-b… read more here.
Keywords: base chordomas; cbl; skull base; cbl cbl ... See more keywords
Double fullerene cathode buffer layers afford highly efficient and stable inverted planar perovskite solar cells
Sign Up to like & getrecommendations! Published in 2020 at "Organic Electronics"
DOI: 10.1016/j.orgel.2020.105726
Abstract: Abstract Fullerene derivatives especially [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) with strong electron-accepting abilities have been commonly implemented as indispensable cathode buffer layers (CBLs) of inverted (p-i-n) planar perovskite solar cells (iPSCs) to facilitate electron transport.… read more here.
Keywords: double fullerene; cbl; cathode; fullerene cbl ... See more keywords
Identification of ABC transporters acting in vitamin B12 metabolism in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2017.11.002
Abstract: Vitamin B12 (cobalamin, Cbl) is a micronutrient essential to human health. Cbl is not utilized as is but must go through complex subcellular and metabolic processing to generate two cofactor forms: methyl-Cbl for methionine synthase,… read more here.
Keywords: abc transporters; vitamin b12; cbl;
Rs4911154 of circ-ITCH aggravated tumor malignancy of thyroid nodules via the circ-ITCH/miR-22-3p/CBL axis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-97471-5
Abstract: Recent evidence revealed an inhibitory effect of circ-ITCH on the progression of papillary thyroid cancer via affecting the circ-ITCH/miR-22-3p/CBL axis. Rs4911154, an SNP located in circ-ITHC, was previously reported to be significantly associated with an… read more here.
Keywords: thyroid nodules; itch; cbl; mir ... See more keywords
Master checkpoint Cbl-b inhibition: Anti-tumour efficacy in a murine colorectal cancer model following siRNA-based cell therapy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz253.057
Abstract: Abstract Background The E3 ubiquitin ligase Cbl-b is a key master immune checkpoint regulator that limits immune activation critical for anti-tumor immunity. We first reported that Cbl-b deficiency in mice confers spontaneous in vivo rejection… read more here.
Keywords: cbl; sirna based; efficacy; anti tumor ... See more keywords
Error Analysis of Customer Baseline Load (CBL) Calculation Methods for Residential Customers
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Transactions on Industry Applications"
DOI: 10.1109/tia.2016.2613985
Abstract: Federal Energy Regulatory Commission (FERC) 745 order has created an environment that allows demand response owners to sell their load reduction in the wholesale market. One of the main challenges that independent system operators and… read more here.
Keywords: calculation methods; cbl; error analysis; analysis ... See more keywords
Improvisation to combat sexual harassment on the wards
Sign Up to like & getrecommendations! Published in 2023 at "Medical Education"
DOI: 10.1111/medu.15036
Abstract: A post-activity survey revealed 87% of students strongly agreed on its usefulness for knowledge consolidation, application of high-yield concepts, and capturing their attention. Faculty observers indicated that students were highly engaged and motivated to work… read more here.
Keywords: cbl; sexual harassment; combat sexual; improvisation combat ... See more keywords
Ubiquitination and functional modification of GluN2B subunit–containing NMDA receptors by Cbl-b in the spinal cord dorsal horn
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aaw1519
Abstract: Peripheral inflammation overrides a developmental, ubiquitin-mediated switch limiting neuronal sensitivity. A painful return to developmental NMDAR activity Neuronal sensitivity is mediated, in part, by NMDA receptor (NMDAR) signaling, and increased abundance of GluN2B-containing NMDARs in… read more here.
Keywords: cbl; glun2b; dorsal horn; inflammation ... See more keywords