C-Cbl and Cbl-b expression in skull base chordomas is associated with tumor progression and poor prognosis.
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DOI: 10.1016/j.humpath.2017.12.019
Abstract: Chordomas are rare, locally aggressive malignancies that are often difficult to eradicate. Surgery and radiotherapy are the first-line treatments, but the probability of local recurrence is high. According to our previous research, c-Cbl and Cbl-b… read more here.
Keywords: base chordomas; cbl; skull base; cbl cbl ... See more keywords
Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy
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DOI: 10.1186/s12871-018-0555-z
Abstract: BackgroundInterleukin 2 (IL-2) influences the development and severity of pain due to its antinociceptive and immunomodulatory effects. Its production is influenced by the increased expression of c-Cbl (Casitas B-lineage lymphoma proto-oncogene) and Cbl-b E3 ubiquitin… read more here.
Keywords: expression cbl; increased expression; ubiquitin ligases; expression ... See more keywords