Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening
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DOI: 10.1038/s41401-019-0256-2
Abstract: The cAMP-responsive element binding protein (CREB) binding protein (CBP) and adenoviral E1A-binding protein (P300) are two closely related multifunctional transcriptional coactivators. Both proteins contain a bromodomain (BrD) adjacent to the histone acetyl transferase (HAT) catalytic… read more here.
Keywords: based high; cbp; cbp brd; fret based ... See more keywords