Hypoxia-Activated CBS/H2S Signaling Drives Drug Resistance in AML through CD36-Mediated Fatty Acid metabolism.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiaf065
Abstract: Hypoxia-associated H2S accumulation promotes chemotherapy resistance in solid tumor cells. This study delved into the mechanism by which CBS/H2S signaling is involved in the development of acute myeloid leukemia (AML) resistance to cytarabine (ara-C) under… read more here.
Keywords: cbs h2s; aml; resistant aml; ara resistant ... See more keywords
Sodium hydrosulfide inhibits hemin-induced ferroptosis and lipid peroxidation in BV2 cells via the CBS/H2S system.
Sign Up to like & getrecommendations! Published in 2023 at "Cellular signalling"
DOI: 10.2139/ssrn.4224101
Abstract: Ferroptosis is a form of iron-dependent programmed cell death discovered in recent years that has been shown to be involved in diverse neurological disorders. Hydrogen sulfide (H2S) is an important signaling molecule with neuroprotective effects,… read more here.
Keywords: lipid peroxidation; induced ferroptosis; hemin induced; cbs h2s ... See more keywords
L-cysteine mitigates busulfan-induced testicular injury through modulation of CBS/H2S axis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2025.1679330
Abstract: Global male infertility, characterized by decreased spermatogenesis and sperm quality, is a significant concern. L-cysteine, essential for hydrogen sulfide (H2S) synthesis, offers numerous biological advantages. However, the protective mechanisms of L-cysteine in treating spermatogenic dysfunction… read more here.
Keywords: cbs h2s; induced testicular; busulfan induced; cysteine ... See more keywords