A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100118
Abstract: Polycomb group (PcG) proteins are epigenetic regulators that facilitate both embryonic development and cancer progression. PcG proteins form Polycomb repressive complexes 1 and 2 (PRC1 and PRC2). PRC2 trimethylates histone H3 lysine 27 (H3K27me3), a… read more here.
Keywords: prostate cancer; selective cbx2; cancer; cbx2 ... See more keywords
Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23500
Abstract: High grade serous ovarian carcinoma (HGSOC) is lethal with insidious onset, rapid progression, poor prognosis, and limited treatment options. Polycomb repressor complexes (PRC) 1 and 2 are intimately involved in progression of many types of… read more here.
Keywords: high grade; grade serous; cbx2; hgsoc ... See more keywords
Novel chromobox 2 inhibitory peptide decreases tumor progression.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on therapeutic targets"
DOI: 10.1080/14728222.2023.2218614
Abstract: BACKGROUND The Polycomb Repressor Complex 1 (PRC1) is an epigenetic regulator of differentiation and development, consisting of multiple subunits including RING1, BMI1, and Chromobox. The composition of PRC1 dictates its function and aberrant expression of… read more here.
Keywords: cbx2; chromobox inhibitory; progression; peptide ... See more keywords
Abstract A081: Chromobox 2 (CBX2) drives an immunosuppressive tumor microenvironment in high grade serous carcinoma (HGSC)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.ovarian23-a081
Abstract: Introduction: Epigenetic reader and component of Polycomb Repressor Complex 1 (PRC1), Chromobox 2 (CBX2) is expressed in greater than 75% of high-grade serous carcinoma (HGSC) tumors. Increased CBX2 expression conveys a poorer disease-free and overall… read more here.
Keywords: cbx2; time; carcinoma; chromobox cbx2 ... See more keywords
Abstract GMM-058: CBX2 IDENTIFIED AS DRIVER OF ANOIKIS ESCAPE AND DISSEMINATION IN HIGH GRADE SEROUS OVARIAN CANCER
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.ovcasymp18-gmm-058
Abstract: The vast majority of high grade serous ovarian carcinomas (HGSOC) are diagnosed at an advanced stage. Chromobox 2 (CBX2), a polycomb repressor complex subunit, plays an oncogenic role in a variety of cancers. In prostate… read more here.
Keywords: high grade; cancer; grade serous; cbx2 ... See more keywords
Cuproptosis-related ceRNA axis triggers cell proliferation and cell cycle through CBX2 in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2024 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-024-02887-0
Abstract: Background Lung adenocarcinoma (LUAD) has high morbidity and mortality. Despite substantial advances in treatment, the prognosis of patients with LUAD remains unfavorable. The ceRNA axis has been reported to play an important role in the… read more here.
Keywords: cbx2; cuproptosis related; cuproptosis; cell ... See more keywords
CBX2 enhances the progression and TMZ chemoresistance of glioma via EZH2-mediated epigenetic silencing of PTEN expression
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1430891
Abstract: Chromobox (CBX) 2, a member of the CBX protein family and a crucial component of the polycomb repressive complex (PRC), exerts significant influence on the epigenetic regulation of tumorigenesis, including glioma. However, the precise role… read more here.
Keywords: cbx2; progression; ezh2; expression ... See more keywords
The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14143491
Abstract: Simple Summary Cancer develops due to the expression of genes that promote cell growth and the repression of genes that limit growth. Epigenetics is a mechanism that regulates gene expression via the chemical modification of… read more here.
Keywords: dream complex; cell growth; cancer; cbx2 ... See more keywords
CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/β-catenin pathway
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11776
Abstract: Gastric cancer (GC) is the most common and fast-growing malignancy of the digestive system, which has a high mortality. Chromobox homolog 2 (CBX2) has been reported to be highly expressed in cancer tissues compared with… read more here.
Keywords: invasion; catenin pathway; yap; cancer ... See more keywords