A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100118
Abstract: Polycomb group (PcG) proteins are epigenetic regulators that facilitate both embryonic development and cancer progression. PcG proteins form Polycomb repressive complexes 1 and 2 (PRC1 and PRC2). PRC2 trimethylates histone H3 lysine 27 (H3K27me3), a… read more here.
Keywords: prostate cancer; selective cbx2; cancer; cbx2 ... See more keywords
Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23500
Abstract: High grade serous ovarian carcinoma (HGSOC) is lethal with insidious onset, rapid progression, poor prognosis, and limited treatment options. Polycomb repressor complexes (PRC) 1 and 2 are intimately involved in progression of many types of… read more here.
Keywords: high grade; grade serous; cbx2; hgsoc ... See more keywords
Novel chromobox 2 inhibitory peptide decreases tumor progression.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on therapeutic targets"
DOI: 10.1080/14728222.2023.2218614
Abstract: BACKGROUND The Polycomb Repressor Complex 1 (PRC1) is an epigenetic regulator of differentiation and development, consisting of multiple subunits including RING1, BMI1, and Chromobox. The composition of PRC1 dictates its function and aberrant expression of… read more here.
Keywords: cbx2; chromobox inhibitory; progression; peptide ... See more keywords
Abstract GMM-058: CBX2 IDENTIFIED AS DRIVER OF ANOIKIS ESCAPE AND DISSEMINATION IN HIGH GRADE SEROUS OVARIAN CANCER
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DOI: 10.1158/1557-3265.ovcasymp18-gmm-058
Abstract: The vast majority of high grade serous ovarian carcinomas (HGSOC) are diagnosed at an advanced stage. Chromobox 2 (CBX2), a polycomb repressor complex subunit, plays an oncogenic role in a variety of cancers. In prostate… read more here.
Keywords: high grade; cancer; grade serous; cbx2 ... See more keywords
The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth
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DOI: 10.3390/cancers14143491
Abstract: Simple Summary Cancer develops due to the expression of genes that promote cell growth and the repression of genes that limit growth. Epigenetics is a mechanism that regulates gene expression via the chemical modification of… read more here.
Keywords: dream complex; cell growth; cancer; cbx2 ... See more keywords
CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/β-catenin pathway
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2020.11776
Abstract: Gastric cancer (GC) is the most common and fast-growing malignancy of the digestive system, which has a high mortality. Chromobox homolog 2 (CBX2) has been reported to be highly expressed in cancer tissues compared with… read more here.
Keywords: invasion; catenin pathway; yap; cancer ... See more keywords