PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.070
Abstract: The proto-oncogene PIM1 encodes Ser/Thr kinase and regulates cell growth, differentiation and apoptosis. However, more and more studies including ours have found that PIM1 can induce senescence in normal human diploid fibroblasts and behave as… read more here.
Keywords: pim1; cbx8; senescence; induced senescence ... See more keywords
Potential Diagnostic and Prognostic Values of CBX8 Expression in Liver Hepatocellular Carcinoma, Kidney Renal Clear Cell Carcinoma, and Ovarian Cancer: A Study Based on TCGA Data Mining
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/1372879
Abstract: Background Chromobox protein homolog 8 (CBX8), a transcriptional repressor, participates in many biological processes in various carcinomas. Cell differentiation, aging, and cell cycle progression are examples of such processes. It is critical to investigate CBX8… read more here.
Keywords: cell; cbx8; cbx8 expression; potential diagnostic ... See more keywords
Negative Regulation of Erythroid Differentiation via the CBX8-TRIM28 Axis
Sign Up to like & getrecommendations! Published in 2021 at "Molecules and Cells"
DOI: 10.14348/molcells.2021.0012
Abstract: Although the mechanism of chronic myeloid leukemia (CML) initiation through BCR/ABL oncogene has been well characterized, CML cell differentiation into erythroid lineage cells remains poorly understood. Using CRISPR-Cas9 screening, we identify Chromobox 8 (CBX8) as… read more here.
Keywords: erythroid differentiation; cell differentiation; cbx8; differentiation ... See more keywords