Effects of CYP3A5 and UGT2B7 variants on steady-state carbamazepine concentrations in Chinese epileptic patients
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DOI: 10.1097/md.0000000000011662
Abstract: Abstract Carbamazepine (CBZ) is a widely used antiepileptic drug with large interindividual variability in serum concentrations. Previous studies found that CYP3A5*3 (rs776746), UGT2B7*2 (802C>T), and UGT2B7*3 (211G>T) variants could change the enzymes’ activity, which may… read more here.
Keywords: cyp3a5 ugt2b7; epileptic patients; steady state; cbz concentrations ... See more keywords
Application of Teeth in Toxicological Analysis of Decomposed Cadavers Using a Carbamazepine-Administered Rat Model
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DOI: 10.3390/diagnostics13020311
Abstract: In a regular autopsy, blood and organs are used to quantify drug and toxicant concentrations; however, specimens such as blood cannot be collected from highly decomposed corpses, making the quantification of drug and toxicants impossible.… read more here.
Keywords: cbz; cbz concentration; blood; cbz concentrations ... See more keywords