Phosphatidylcholine in bile-derived small extracellular vesicles as a novel biomarker of cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5973
Abstract: BACKGROUND Owing to the lack of definite diagnostic modalities, it is challenging to distinguish malignant cases of cholangiocarcinoma (CCA), which often causes biliary tract obstruction, from benign ones. Here, we investigated a novel lipid biomarker… read more here.
Keywords: extracellular vesicles; cca; small extracellular; derived small ... See more keywords
OTUD6B promotes cholangiocarcinoma growth by regulating STAT3 phosphorylation through deubiquitination of PTK2
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DOI: 10.1002/cbin.12234
Abstract: Cholangiocarcinoma (CCA) is a hepatobiliary carcinoma with uncontrolled cell proliferation, poor prognosis, and high mortality. The ovarian tumor structural domain (OTU) containing protein 6B (OTUD6B) belongs to the OTU deubiquitin family and is vital in… read more here.
Keywords: cca; phosphorylation; tumor; cell ... See more keywords
Disentangling poststroke cognitive deficits and their neuroanatomical correlates through combined multivariable and multioutcome lesion‐symptom mapping
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26208
Abstract: Studies in patients with brain lesions play a fundamental role in unraveling the brain's functional anatomy. Lesion‐symptom mapping (LSM) techniques can relate lesion location to cognitive performance. However, a limitation of current LSM approaches is… read more here.
Keywords: lesion symptom; combined multivariable; cca; symptom mapping ... See more keywords
Extracellular vesicles as therapeutic carriers of microRNAs for cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28925
Abstract: Cholangiocarcinoma (CCA) is a lethal malignancy originating from the biliary tree. Because CCA is usually detected in advanced stages, patients are infrequently eligible for surgery, which is the only curative intervention. Unfortunately, there are currently… read more here.
Keywords: extracellular vesicles; cholangiocarcinoma; cca; cell ... See more keywords
Fibroblast Growth Factor Receptor Inhibition for Cholangiocarcinoma: Looking Through a Door Half‐Opened
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DOI: 10.1002/hep.30069
Abstract: Cholangiocarcinoma (CCA), the most common biliary tract malignancy, represents a heterogeneous group of epithelial cancers arising from varying locations within the biliary tree. The anatomical subtypes of CCA are intrahepatic CCA (iCCA), which arises in… read more here.
Keywords: fibroblast growth; cholangiocarcinoma; cca; growth factor ... See more keywords
Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30210
Abstract: Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy frequently complicated by cholangiocarcinoma (CCA). Massive proliferation of biliary tree stem/progenitor cells (BTSCs), expansion of peribiliary glands (PBGs), and dysplasia were observed in PSC. The aims… read more here.
Keywords: cca; primary sclerosing; stem; cell ... See more keywords
Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30656
Abstract: Although the multi‐tyrosine kinase inhibitor sorafenib is useful in the treatment of several cancers, cholangiocarcinoma (CCA) is refractory to this drug. Among other mechanisms of chemoresistance, impaired uptake through human organic cation transporter type 1… read more here.
Keywords: gene therapy; cca; hoct1; gene ... See more keywords
Dependency of Cholangiocarcinoma on Cyclin D–Dependent Kinase Activity
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30704
Abstract: Cholangiocarcinoma (CCA) is a bile duct cancer with a very poor prognosis. Currently, there is no effective pharmacological treatment available for it. We showed that CCA ubiquitously relies on cyclin‐dependent kinases 4 and 6 (CDK4/6)… read more here.
Keywords: cyclin dependent; cdk4; cholangiocarcinoma; cca ... See more keywords
Type 3 Inositol 1,4,5‐Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30839
Abstract: Cholangiocarcinoma (CCA) is the second most common malignancy arising in the liver. It carries a poor prognosis, in part because its pathogenesis is not well understood. The type 3 inositol 1,4,5‐trisphosphate receptor (ITPR3) is the… read more here.
Keywords: microscopy; type inositol; cca; inositol trisphosphate ... See more keywords
The Tumor Microenvironment in Cholangiocarcinoma Progression
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31410
Abstract: Cholangiocarcinoma (CCA) is an aggressive and heterogeneous malignancy of the biliary tree. A typical hallmark of CCA is that cancer cells are embedded into a dense stroma containing fibrogenic cells, lymphatics and a variety of… read more here.
Keywords: cholangiocarcinoma; cca; progression; tumor microenvironment ... See more keywords
Differences in risk factors for molecular subtypes of clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33701
Abstract: The ccA and ccB molecular subtypes of clear cell renal cell carcinoma (ccRCC) have well‐characterized prognostic relevance. However, it is not known whether they possess distinct etiologies. We investigated the relationships between these subtypes and… read more here.
Keywords: risk; risk factors; cca; case ... See more keywords