Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09964-6
Abstract: Cholangiocarcinoma (CCA) is a lethal cancer with rapid progression and poor survival. Novel and more effective therapies than those currently available are, therefore, urgently needed. Our research group previously reported the combination of gemcitabine and… read more here.
Keywords: cytotoxicity; cca cells; treatment; combination gemcitabine ... See more keywords
miR-28-5p inhibits cholangiocarcinoma progression and predicts good prognosis of patients
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2085359
Abstract: ABSTRACT Cholangiocarcinoma (CCA) is one of the most common hepatic and biliary malignancies. The overall five-year survival rate for cholangiocarcinoma is less than 15%. miR-28-5p has been reported to participate the development of various human… read more here.
Keywords: cca cells; prognosis; cca; growth metastasis ... See more keywords
Metformin Exerts Antiproliferative and Anti-metastatic Effects Against Cholangiocarcinoma Cells by Targeting STAT3 and NF-ĸB.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.11296
Abstract: BACKGROUND/AIM Cholangiocarcinoma (CCA) is an aggressive cancer for which standard treatments are still ineffective. This study demonstrated the antiproliferative and anti-metastatic activity of metformin, an anti-diabetic drug, in CCA cells. MATERIALS AND METHODS Cell proliferation,… read more here.
Keywords: metformin exerts; cca cells; metformin; cca ... See more keywords
CD44v9 Induces Stem Cell-Like Phenotypes in Human Cholangiocarcinoma
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DOI: 10.3389/fcell.2020.00417
Abstract: Background: Our previous study demonstrated an overexpression of CD44 variant 9 (CD44v9) in human cholangiocarcinoma (CCA) tissues that was associated with inflammation-related tumor development. However, the participation of CD44v9 in cholangiocarcinogenesis remains poorly understood. Therefore,… read more here.
Keywords: cca cells; human cholangiocarcinoma; cd44v9; expression levels ... See more keywords
13-cis-retinoic acid inhibits the self-renewal, migration, invasion and adhesion of cholangiocarcinoma cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2023.5223
Abstract: 13-cis-retinoic acid (13CRA), a Food and Drug Administration-approved drug for severe acne, is currently being investigated for its potential use in skin cancer prevention. 13CRA has been reported to exhibit antitumor effects against various types… read more here.
Keywords: invasion adhesion; adhesion; cell; cca cells ... See more keywords
MiR-206 suppresses the deterioration of intrahepatic cholangiocarcinoma and promotes sensitivity to chemotherapy by inhibiting interactions with stromal CAFs
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.62602
Abstract: Background: Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant subtype of cholangiocarcinoma (CCA) with poor prognosis. In iCCA, the interplay between the stroma and tumor cells results in resistance to adjuvant chemotherapy. Increasing evidence indicates that… read more here.
Keywords: deterioration; cafs; icca; mir 206 ... See more keywords