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   Articles with "ccat2" as a keyword



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Long non-coding RNA CCAT2 as a potential serum biomarker for diagnosis and prognosis of multiple myeloma

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recommendations! Published in 2020 at "Annals of Hematology"

DOI: 10.1007/s00277-020-04161-9

Abstract: Increasing knowledge of long non-coding RNAs (lncRNAs) has shown that they can be used as circulating tumor markers. Also, considerable evidences have revealed that lncRNAs have important roles in tumor diagnosis and prognosis. The lncRNA… read more here.

Keywords: diagnosis prognosis; ccat2; long non; serum ... See more keywords
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Expression of lncRNA CCAT2 in children with neuroblastoma and its effect on cancer cell growth

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recommendations! Published in 2021 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-020-04042-9

Abstract: The aim of this study was to determine the expression of long-chain non-coding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) in children with neuroblastoma and its effect on cancer cell growth. A polymerase chain reaction… read more here.

Keywords: group; ccat2; children neuroblastoma; expression ... See more keywords
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LncRNA CCAT2 expression at diagnosis predicts imatinib response in chronic phase chronic myeloid leukemia patients.

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recommendations! Published in 2022 at "Leukemia research"

DOI: 10.1016/j.leukres.2022.106838

Abstract: Long noncoding RNAs (lncRNAs) are identified as key players in the initiation, development, and prognosis of chronic myeloid leukemia (CML). Some lncRNAs are expected to serve as diagnostic biomarkers, predictors of clinical outcomes and therapeutic… read more here.

Keywords: expression; ccat2; response; chronic phase ... See more keywords
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Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.

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recommendations! Published in 2018 at "Genome research"

DOI: 10.1101/gr.225128.117

Abstract: The cancer-risk-associated rs6983267 single nucleotide polymorphism (SNP) and the accompanying long noncoding RNA CCAT2 in the highly amplified 8q24.21 region have been implicated in cancer predisposition, although causality has not been established. Here, using allele-specific… read more here.

Keywords: rna; ccat2; associated rs6983267; snp accompanying ... See more keywords

Long noncoding RNA CCAT2 reduces chemosensitivity to 5‐fluorouracil in breast cancer cells by activating the mTOR axis

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recommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.17041

Abstract: Breast cancer (BC) is the most prevalent cancer in women and the second leading cause for cancer‐related death in women. LncRNA CCAT2 is involved in BC cell drug sensitivity. Drug resistance of BC cells after… read more here.

Keywords: ccat2; breast; expression; mtor pathway ... See more keywords
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Long non-coding RNA CCAT2 is associated with poor prognosis in hepatocellular carcinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial–mesenchymal transition

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recommendations! Published in 2017 at "OncoTargets and therapy"

DOI: 10.2147/ott.s127100

Abstract: Increasing evidence has demonstrated that aberrant expressions of long non-coding RNAs (lncRNAs) are involved in various malignancies, including hepatocellular carcinoma (HCC). This study aimed to investigate the role of lncRNA colon cancer-associated transcript 2 (CCAT2)… read more here.

Keywords: hcc; ccat2 expression; ccat2; long non ... See more keywords
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Silencing of Long Non-Coding RNA Colon Cancer-Associated Transcript 2 Inhibits the Growth and Metastasis of Gastric Cancer Through Blocking mTOR Signaling

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recommendations! Published in 2020 at "OncoTargets and therapy"

DOI: 10.2147/ott.s220302

Abstract: Purpose This study aimed to evaluate the specific role of colon cancer-associated transcript 2 (CCAT2) on gastric cancer (GC), and reveal the potential regulatory mechanism relating to mammalian target of rapamycin (mTOR) signaling. Methods The… read more here.

Keywords: ccat2; mtor; mtor signaling; cancer associated ... See more keywords
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Long Non-Coding RNA CCAT2 Promotes the Development of Esophageal Squamous Cell Carcinoma by Inhibiting miR-200b to Upregulate the IGF2BP2/TK1 Axis

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.680642

Abstract: Long non-coding RNAs (lncRNAs) have been shown to play important roles in human cancers, including esophageal squamous cell carcinoma (ESCC). In the current study, we identified CCAT2 as a relevant lncRNA and investigated its role… read more here.

Keywords: ccat2; mir 200b; escc; expression ... See more keywords
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Dual Function of CCAT2 in Regulating Luminal Subtype of Breast Cancer Depending on the Subcellular Distribution

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recommendations! Published in 2023 at "Cancers"

DOI: 10.3390/cancers15020538

Abstract: Simple Summary Long non-coding RNAs have been demonstrated to play important roles in regulating tumor development and progression in breast cancer, which is tumor type dependent and cellular localization dependent. However, the regulatory mechanisms remain… read more here.

Keywords: ccat2; cell; breast cancer; tumor ... See more keywords
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Association of lncRNA CCAT2 and CASC8 Gene Polymorphisms with Hepatocellular Carcinoma

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recommendations! Published in 2019 at "International Journal of Environmental Research and Public Health"

DOI: 10.3390/ijerph16162833

Abstract: The worldwide incidence of hepatocellular carcinoma (HCC), the major histological type of primary liver cancer, is heterogeneous due to the variable prevalence of etiological factors, indicating a correlation of HCC risk with genetic variations among… read more here.

Keywords: hcc; gene polymorphisms; ccat2; casc8 gene ... See more keywords
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Knockdown of Long Noncoding RNA CCAT2 Inhibits Cellular Proliferation, Invasion, and Epithelial–Mesenchymal Transition in Glioma Cells

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recommendations! Published in 2017 at "Oncology Research"

DOI: 10.3727/096504016x14792098307036

Abstract: Long noncoding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) has been demonstrated to play an important role in diverse tumorigenesis. However, the biological function of lncRNAs in glioma is still unknown. In this study, we… read more here.

Keywords: long noncoding; glioma; noncoding rna; ccat2 ... See more keywords