PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29133
Abstract: Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. The covalently closed circular DNA (cccDNA) minichromosome, which serves as the template for the transcription of viral RNAs, plays a key role in… read more here.
Keywords: pregenomic rna; transcription; cccdna; prmt5 ... See more keywords
Sphondin efficiently blocks HBsAg production and cccDNA transcription through promoting HBx degradation
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28578
Abstract: Hepatitis B surface antigen (HBsAg) loss and seroconversion, which is considered as functional cure of chronic Hepatitis B virus (HBV) infection, is rarely achieved even after long‐term antiviral treatments. Therefore, new antiviral strategies interfering with… read more here.
Keywords: sphondin; cccdna transcription; hbsag production; cccdna ... See more keywords
Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.05.003
Abstract: Abstract The hepatitis B core protein (HBc) has been suggested to interact with covalently closed circular DNA (cccDNA) and regulate hepatitis B virus (HBV) transcription. However, direct evidence is lacking. We aimed to identify the… read more here.
Keywords: cccdna; hbv transcription; hepatitis; hbc ... See more keywords
Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and non‐epigenetic manners
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.03.008
Abstract: &NA; Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), the stable genomic form as the template for viral transcription, plays a crucial role in viral persistence which remains a major global health problem. While… read more here.
Keywords: transcription; cccdna; hbv; zhx2 ... See more keywords
Characterization of the molecular events of covalently closed circular DNA synthesis in de novo Hepatitis B virus infection of human hepatoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2019.01.004
Abstract: ABSTRACT Despite the utmost importance of cccDNA in HBV biology, the mechanism by which cccDNA synthesis is regulated is not completely understood. Here we explored HepG2‐NTCP cell line and performed a time‐course HBV infection experiment… read more here.
Keywords: cccdna; dna; infection; time ... See more keywords
IFN-α2b inhibits the ethanol enriched-HBV cccDNA through blocking a positive feedback loop of HBx/MSL2/cccDNA/HBV/HBx in liver.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.057
Abstract: Hepatitis B virus (HBV) is a major risk factor for liver diseases, in which HBV covalently closed circular DNA (cccDNA), as the genomic form that templates viral transcription, plays crucial roles in sustaining viral persistence.… read more here.
Keywords: cccdna; hbv; liver; cccdna hbv ... See more keywords
A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA
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DOI: 10.1016/j.jcmgh.2021.11.011
Abstract: Background and Aims The persistence of viral covalently closed circular DNA (cccDNA) is the major obstacle for antiviral treatment against hepatitis B virus (HBV). Basic and translational studies are largely hampered due to the lack… read more here.
Keywords: virus; mouse model; cccdna; aav hbv1 ... See more keywords
Quantification of intrahepatic cccDNA in HBV associated hepatocellular carcinoma by improved ddPCR method.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2021.114334
Abstract: The quantification of intrahepatic covalently closed circular DNA (cccDNA) is important for assessing the efficiency of anti-HBV therapy. Exonuclease treatment is essential before real-time quantitative PCR (qPCR) or droplet digital PCR (ddPCR) measurement to improve… read more here.
Keywords: cccdna; intrahepatic cccdna; exonuclease; quantification ... See more keywords
Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.04.028
Abstract: BACKGROUND More than half of hepatocellular carcinomas (HCCs) are etiologically attributed to hepatitis B virus (HBV) infection, but it remains unclear whether HBV mutations are virological factors that contribute to formation of HCC or instead… read more here.
Keywords: hbv related; analysis; cccdna; hepatitis virus ... See more keywords
Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02215
Abstract: Chronic hepatitis B virus (HBV) infection is a worldwide disease that causes thousands of deaths per year. Currently, there is no therapeutic that can completely cure already infected HBV patients due to the inability of… read more here.
Keywords: cccdna reducers; infection; hepatitis virus; cccdna ... See more keywords
HBV cccDNA—A Culprit and Stumbling Block for the Hepatitis B Virus Infection: Its Presence in Hepatocytes Perplexed the Possible Mission for a Functional Cure
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02216
Abstract: Hepatitis B virus infection (HBV) is still a big health problem across the globe. It has been linked to the development of liver cirrhosis and hepatocellular carcinoma and can trigger different types of liver damage.… read more here.
Keywords: functional cure; hbv; hepatitis virus; biology ... See more keywords