IFN-α2b inhibits the ethanol enriched-HBV cccDNA through blocking a positive feedback loop of HBx/MSL2/cccDNA/HBV/HBx in liver.
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DOI: 10.1016/j.bbrc.2020.04.057
Abstract: Hepatitis B virus (HBV) is a major risk factor for liver diseases, in which HBV covalently closed circular DNA (cccDNA), as the genomic form that templates viral transcription, plays crucial roles in sustaining viral persistence.… read more here.
Keywords: cccdna; hbv; liver; cccdna hbv ... See more keywords