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   Articles with "cccdna transcription" as a keyword



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Sphondin efficiently blocks HBsAg production and cccDNA transcription through promoting HBx degradation

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recommendations! Published in 2023 at "Journal of Medical Virology"

DOI: 10.1002/jmv.28578

Abstract: Hepatitis B surface antigen (HBsAg) loss and seroconversion, which is considered as functional cure of chronic Hepatitis B virus (HBV) infection, is rarely achieved even after long‐term antiviral treatments. Therefore, new antiviral strategies interfering with… read more here.

Keywords: sphondin; cccdna transcription; hbsag production; cccdna ... See more keywords

Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx.

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recommendations! Published in 2020 at "Journal of hepatology"

DOI: 10.1016/j.jhep.2020.09.019

Abstract: BACKGROUND Current antiviral therapies help keep hepatitis B virus (HBV) under control, but they are not curative. A cure for chronic hepatitis B (CHB) is lacking due to the inability of current therapies to eliminate… read more here.

Keywords: dicoumarol; hbv; hbx; cccdna transcription ... See more keywords
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Interferon Alpha Induces Multiple Cellular Proteins That Coordinately Suppress Hepadnaviral Covalently Closed Circular DNA Transcription

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recommendations! Published in 2020 at "Journal of Virology"

DOI: 10.1128/jvi.00442-20

Abstract: Pegylated IFN-α is the only therapeutic regimen that can induce a functional cure of chronic hepatitis B in a small, but significant, fraction of treated patients. Understanding the mechanisms underlying the antiviral functions of IFN-α… read more here.

Keywords: cccdna; cccdna transcription; stat1 smchd1; transcription ... See more keywords
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Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation

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recommendations! Published in 2022 at "Journal of Virology"

DOI: 10.1128/jvi.01362-22

Abstract: Hepatitis B virus (HBV) core protein (HBc) has emerged as a promising antiviral target. However, whether HBc can regulate HBV covalently closed circular DNA (cccDNA) transcription remains elusive. This study illustrated that HBc has no… read more here.

Keywords: dna; hbv; transcription; cccdna transcription ... See more keywords