Investigating the effect of ribavirin treatment on genetic mutations in Crimean–Congo haemorrhagic fever virus (CCHFV) through next‐generation sequencing
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DOI: 10.1002/jmv.28548
Abstract: Crimean–Congo haemorrhagic fever (CCHF) is the most widespread tick‐borne viral haemorrhagic fever affecting humans, and yet a licensed drug against the virus (CCHFV) is still not available. While several studies have suggested the efficacy of… read more here.
Keywords: ribavirin; haemorrhagic fever; effect; cchfv ... See more keywords
Expression and characterization of codon-optimized Crimean-Congo hemorrhagic fever virus Gn glycoprotein in insect cells
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DOI: 10.1007/s00705-017-3315-3
Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is a major cause of tick-borne viral hemorrhagic disease in the world. Despite of its importance as a deadly pathogen, there is currently no licensed vaccine against CCHF disease. The… read more here.
Keywords: hemorrhagic; cchfv; expression; congo hemorrhagic ... See more keywords
Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China
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DOI: 10.1007/s12250-018-0020-7
Abstract: Crimean-Congo hemorrhagic fever (CCHF) caused by the CCHF virus (CCHFV) is a tick-borne natural focal disease with a mortality rate of approximately 50%. CCHFV is widely prevalent in Africa, southern Asia, the Middle East, and… read more here.
Keywords: cchfv strains; xinjiang; cchfv; xinjiang province ... See more keywords
Identification of 2′‐deoxy‐2′‐fluorocytidine as a potent inhibitor of Crimean‐Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus
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DOI: 10.1016/j.antiviral.2017.10.008
Abstract: Abstract Crimean‐Congo hemorrhagic fever virus (CCHFV), a tick‐borne orthonairovirus, causes a severe hemorrhagic disease in humans (Crimean‐Congo hemorrhagic fever, CCHF). Currently, no vaccines are approved to prevent CCHF; treatment is limited to supportive care and… read more here.
Keywords: reporter; cchfv; virus; identification ... See more keywords
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever
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DOI: 10.1016/j.cell.2021.05.001
Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for which specific treatments and vaccines are urgently needed. Here, we characterize the human immune… read more here.
Keywords: hemorrhagic; hemorrhagic fever; cchfv; protective neutralizing ... See more keywords
Purification of Crimean–Congo hemorrhagic fever virus nucleoprotein and its utility for serological diagnosis
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DOI: 10.1038/s41598-021-81752-0
Abstract: Crimean–Congo hemorrhagic fever virus (CCHFV) causes a zoonotic disease, Crimean–Congo hemorrhagic fever (CCHF) endemic in Africa, Asia, the Middle East, and Southeastern Europe. However, the prevalence of CCHF is not monitored in most of the… read more here.
Keywords: hemorrhagic fever; congo hemorrhagic; cchfv; crimean congo ... See more keywords
Nucleoside-modified mRNA vaccines protect IFNAR-/- mice against Crimean Congo hemorrhagic fever virus infection.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of virology"
DOI: 10.1128/jvi.01568-21
Abstract: Crimean-Congo hemorrhagic fever (CCHF), caused by Crimean-Congo hemorrhagic fever virus (CCHFV), is on the World Health Organizations' list of prioritized diseases and pathogens. With global distribution, high fatality rate and no approved vaccine or effective… read more here.
Keywords: fever; hemorrhagic fever; infection; cchfv ... See more keywords
The host inflammatory response contributes to disease severity in Crimean-Congo hemorrhagic fever virus infected mice
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DOI: 10.1371/journal.ppat.1010485
Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen. In cell culture, CCHFV is sensed by the cytoplasmic RNA sensor retinoic acid-inducible gene I (RIG-I) molecule and its adaptor molecule mitochondrial antiviral signaling (MAVS)… read more here.
Keywords: crimean congo; hemorrhagic fever; cchfv; mice ... See more keywords
Development of anti-Crimean-Congo hemorrhagic fever virus Gc and NP-specific ELISA for detection of antibodies in domestic animal sera
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.913046
Abstract: Crimean-Congo hemorrhagic fever (CCHF) is a priority emerging disease. CCHF, caused by the CCHF virus (CCHFV), can lead to hemorrhagic fever in humans with severe cases often having fatal outcomes. CCHFV is maintained within a… read more here.
Keywords: crimean congo; hemorrhagic fever; cchfv; virus ... See more keywords
A Novel RT-LAMP for the Detection of Different Genotypes of Crimean–Congo Haemorrhagic Fever Virus in Patients from Spain
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076411
Abstract: Crimean–Congo haemorrhagic fever (CCHF) is a potentially lethal tick-borne viral disease with a wide distribution. In Spain, 12 human cases of CCHF have been confirmed, with four deaths. The diagnosis of CCHF is hampered by… read more here.
Keywords: crimean congo; lamp; detection different; congo haemorrhagic ... See more keywords
Serological Prevalence of Crimean–Congo Hemorrhagic Fever Virus Infection in Small Ruminants and Cattle in The Gambia
Sign Up to like & getrecommendations! Published in 2023 at "Pathogens"
DOI: 10.3390/pathogens12060749
Abstract: Crimean–Congo hemorrhagic fever virus (CCHFV) is a widely distributed tickborne zoonotic agent that infects a variety of host species. There is a lack of information on the true geographic distribution of the prevalence and risk… read more here.
Keywords: small ruminants; crimean congo; prevalence; hemorrhagic fever ... See more keywords