Hyperbaric oxygenation alleviates chronic constriction injury (CCI)-induced neuropathic pain and inhibits GABAergic neuron apoptosis in the spinal cord
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Pain"
DOI: 10.1016/j.sjpain.2017.08.014
Abstract: Abstract Background and aims Dysfunction of GABAergic inhibitory controls contributes to the development of neuropathic pain. We examined our hypotheses that (1) chronic constriction injury (CCI)-induced neuropathic pain is associated with increased spinal GABAergic neuron… read more here.
Keywords: cci induced; apoptosis; induced neuropathic; neuropathic pain ... See more keywords
Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2053032
Abstract: ABSTRACT Forkhead box O1 (FoxO1) is a critical molecule in modulating cell growth, differentiation and metabolism, acting as a vital transcription factor. This study explored the role of FoxO1 in chronic constriction injury (CCI)-induced neuropathic… read more here.
Keywords: foxo1 aqp5; model; cci induced; cci ... See more keywords
Antinociceptive Effects of Aaptamine, a Sponge Component, on Peripheral Neuropathy in Rats
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DOI: 10.3390/md21020113
Abstract: Aaptamine, a natural marine compound isolated from the sea sponge, has various biological activities, including delta-opioid agonist properties. However, the effects of aaptamine in neuropathic pain remain unclear. In the present study, we used a… read more here.
Keywords: aaptamine sponge; ldha expression; antinociceptive effects; sponge component ... See more keywords