Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110670
Abstract: Factors released from glioma-associated microglia/macrophages (GAMs) play a crucial role in glioblastoma multiforme (GBM) progression. Here, we study the importance of CCL18, a cytokine expressed in human but not in rodent GAMs, as a modulator… read more here.
Keywords: glioma; ccl18; model; promotes glioma ... See more keywords
CCL18 – Beyond chemotaxis
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.01.023
Abstract: HighlightsCCL18 is constitutively expressed and up‐regulated in diseases.CCL18 has a weak chemotactic activity toward multiple immune cells including Treg.CCL18 inhibits chemokine‐related cell recruitment by binding to glycosaminoglycans.CCL18 gives immune cells a regulatory phenotype and function… read more here.
Keywords: beyond chemotaxis; cell recruitment; ccl18 beyond; ccl18 ... See more keywords
The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.04.008
Abstract: BACKGROUND Localized Scleroderma (LoS) encompasses a group of idiopathic skin conditions characterized by (sub)cutaneous inflammation and subsequent development of fibrosis. Currently, lack of accurate tools enabling disease activity assessment leads to suboptimal treatment approaches. OBJECTIVE… read more here.
Keywords: biomarker; disease; serum; disease activity ... See more keywords
miR-128 targets the CC chemokine ligand 18 gene (CCL18) in cutaneous malignant melanoma progression.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2018.06.011
Abstract: BACKGROUND The CC chemokine ligand 18 (CCL18) has a higher expression in some tumors, while the CCL18 level can be a marker of tumor progression and prognosis. We previously reported that the expression of CCL18… read more here.
Keywords: melanoma; chemokine ligand; mir 128; expression ... See more keywords
CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac097
Abstract: CCL18 has recently been implicated in malignancies and is increasingly mentioned as a potential tumoral biomarker and furtherly a molecular target for therapeutic intervention, but its expression and clinical significance in multiple myeloma have not… read more here.
Keywords: ccl18; migration invasion; multiple myeloma; myeloma ... See more keywords
Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30
Sign Up to like & getrecommendations! Published in 2020 at "AntiCancer Research"
DOI: 10.21873/anticanres.14291
Abstract: Background/Aim: C-C motif chemokine ligand 18 (CCL18) is overexpressed in the microenvironment of tumors, promotes invasion and metastasis and is thus important for the therapeutic outcome of many tumor entities. The Gs-coupled seven-transmembrane receptor GPR30… read more here.
Keywords: stimulation; gpr30; signaling pathway; expression ... See more keywords
Natural Killer Cells from Allergic Donors Are Defective in Their Response to CCL18 Chemokine
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22083879
Abstract: Natural killer (NK) cells were originally described as cytolytic effector cells, but since then have been recognized to possess regulatory functions on immune responses. Chemokines locate NK cells throughout the body in homeostatic and pathological… read more here.
Keywords: response; natural killer; cells allergic; ccl18 ... See more keywords
CCL18 overexpression predicts a worse prognosis in oral squamous cell carcinoma (OSCC).
Sign Up to like & getrecommendations! Published in 2020 at "Neoplasma"
DOI: 10.4149/neo_2020_190821n802
Abstract: Oral squamous cell carcinoma (OSCC) presents severe morbidity and high mortality owing to local recurrence or remote metastasis. Molecular markers, including chemokines, might provide more efficient prognostic information or even therapeutic targets for the treatment… read more here.
Keywords: time; oral squamous; cell carcinoma; ccl18 ... See more keywords