Therapeutic effects of anti-GM2 CAR-T cells expressing IL-7 and CCL19 for GM2-positive solid cancer in xenograft model.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5907
Abstract: BACKGROUND While chimeric antigen receptor (CAR)-T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in solid cancers has yet to be achieved. One of the reasons for such hurdle is a… read more here.
Keywords: car; anti gm2; car cells; cancer ... See more keywords
Identification of CCL19 as a Novel Immune-Related Biomarker in Diabetic Nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.830437
Abstract: Diabetic nephropathy (DN) is one of the major microvascular complications in diabetic patients and the leading cause of end-stage renal disease (ESRD). Previous studies found that immune-related genes and immune cell infiltration play important roles… read more here.
Keywords: immune related; diabetic nephropathy; ccl19; related biomarker ... See more keywords
Induced expression of CCL19 promotes the anti-tumor ability of CAR-T cells by increasing their infiltration ability
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.958960
Abstract: Background Chimeric antigen receptor-engineered T cell (CAR-T) therapy has shown promising potential for anti-cancer treatment. However, for pancreatic ductal adenocarcinoma (PDAC), the lack of infiltrative ability of these CAR-T cells leads to sub-optimal treatment outcome.… read more here.
Keywords: ability car; tumor; car; car cells ... See more keywords
Infectious bursal disease virus replication is inhibited by avain T cell chemoattractant chemokine CCL19
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.912908
Abstract: Chemokine CCL19, together with its receptor CCR7, is one of the most important factors recruiting immune cells into target organ during virus infection. Our previous study has shown that CCL19 played a vital role in… read more here.
Keywords: bursal disease; chemokine ccl19; replication; disease virus ... See more keywords