Therapeutic effects of anti-GM2 CAR-T cells expressing IL-7 and CCL19 for GM2-positive solid cancer in xenograft model.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5907
Abstract: BACKGROUND While chimeric antigen receptor (CAR)-T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in solid cancers has yet to be achieved. One of the reasons for such hurdle is a… read more here.
Keywords: car; anti gm2; car cells; cancer ... See more keywords
miR-7213-5p-mediated suppression of CCL19 in fibroblast cells may attenuate lupus nephritis
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-025-01960-0
Abstract: Lupus nephritis (LN) is an immune-complex nephritis and one of the most severe organ manifestations of systemic lupus erythematosus. To elucidate the mechanisms underlying LN, we firstly performed comprehensive RNA sequencing and microRNA (miRNA) sequencing… read more here.
Keywords: ccl19; nephritis; mrl lpr; mir 7213 ... See more keywords
Abstract 2823: Development of an in vitro blood-brain barrier model of CCR7/CCL19 induced invasion of the central nervous system
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2823
Abstract: Pediatric T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematological malignancy, is characterized by abnormal thymocyte proliferation, frequently with mutations of the Notch-1 gene and has an overall 10-year survival rate of ~27%. A marker of… read more here.
Keywords: system; ccl19; migration; cell ... See more keywords
CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to skin in lichen planus
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DOI: 10.1172/jci.insight.179899
Abstract: Lichen planus (LP) is a chronic, debilitating, inflammatory disease of the skin and mucous membranes that affects 1%–2% of Americans. Its molecular pathogenesis remains poorly understood, and there are no FDA-approved treatments. We performed single-cell… read more here.
Keywords: lichen planus; ccl19; cxcl9 cxcl10; cxcl10 ccl19 ... See more keywords
Identification of CCL19 as a Novel Immune-Related Biomarker in Diabetic Nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.830437
Abstract: Diabetic nephropathy (DN) is one of the major microvascular complications in diabetic patients and the leading cause of end-stage renal disease (ESRD). Previous studies found that immune-related genes and immune cell infiltration play important roles… read more here.
Keywords: immune related; diabetic nephropathy; ccl19; related biomarker ... See more keywords
Induced expression of CCL19 promotes the anti-tumor ability of CAR-T cells by increasing their infiltration ability
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.958960
Abstract: Background Chimeric antigen receptor-engineered T cell (CAR-T) therapy has shown promising potential for anti-cancer treatment. However, for pancreatic ductal adenocarcinoma (PDAC), the lack of infiltrative ability of these CAR-T cells leads to sub-optimal treatment outcome.… read more here.
Keywords: ability car; tumor; car; car cells ... See more keywords
Infectious bursal disease virus replication is inhibited by avain T cell chemoattractant chemokine CCL19
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.912908
Abstract: Chemokine CCL19, together with its receptor CCR7, is one of the most important factors recruiting immune cells into target organ during virus infection. Our previous study has shown that CCL19 played a vital role in… read more here.
Keywords: bursal disease; chemokine ccl19; replication; disease virus ... See more keywords
Macrophage Inflammatory Proteins (MIPs) Contribute to Malignant Potential of Colorectal Polyps and Modulate Likelihood of Cancerization Associated with Standard Risk Factors
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25031383
Abstract: Better understanding of molecular changes leading to neoplastic transformation is prerequisite to optimize risk assessment and chemopreventive and surveillance strategies. Data on macrophage inflammatory proteins (MIPs) in colorectal carcinogenesis are scanty and their clinical relevance… read more here.
Keywords: ccl19; ccl3; macrophage inflammatory; risk ... See more keywords
Signaling via C-C Chemokine Ligand 19 and Extracellular Regulated Kinase 5 in T Cells Limits the Humoral Adaptive Immune Response in Mice
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26199744
Abstract: Misregulation of C-C chemokine receptor 7 (CCR7) has been linked to multiple autoimmune diseases including systemic lupus erythematosus, multiple sclerosis, and ankylosing spondylitis. As a G-protein-coupled receptor, located on the cell membrane, CCR7 can be… read more here.
Keywords: mice; ccl19; immune response; chemokine ligand ... See more keywords