Kif4A mediate the accumulation and reeducation of THP-1 derived macrophages via regulation of CCL2-CCR2 expression in crosstalking with OSCC
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02261-7
Abstract: Crosstalk between tumor infiltrating macrophages and tumor cells is thought to play an indispensable role in oral squamous cell carcinomas (OSCC) by induction and maintenance of tolerance microenvironment. High infiltration of M2 macrophages and increasing… read more here.
Keywords: ccl2 ccr2; expression; macrophages via; kif4a ... See more keywords
Targeting the CCL2-CCR2 axis for atheroprotection.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac094
Abstract: Decades of research have established atherosclerosis as an inflammatory disease. Only recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-inflammatory strategies with respect to cardiovascular events, thus offering a new paradigm for… read more here.
Keywords: targeting ccl2; axis atheroprotection; ccr2; ccl2 ccr2 ... See more keywords
miR-506-3p Relieves Neuropathic Pain following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neuroscience"
DOI: 10.1159/000528450
Abstract: Neuroinflammation results in neuropathic pain (NP) following brachial plexus avulsion (BPA). This research was designed for investigating the function of miR-506-3p in BPA-induced NP. A total brachial plexus root avulsion model was produced in adult… read more here.
Keywords: mir 506; ccl2 ccr2; brachial plexus; avulsion ... See more keywords
Pharmacological Targeting of the CCL2/CCR2 Axis for Atheroprotection: A Meta-Analysis of Preclinical Studies
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.317492
Abstract: Background: The CCL2 (CC-chemokine ligand 2)/CCR2 (CC-chemokine receptor 2) axis governs monocyte recruitment to atherosclerotic lesions. Genetic and epidemiological studies show strong associations of CCL2 levels with atherosclerotic disease. Still, experimental studies testing pharmacological inhibition… read more here.
Keywords: ccl2 ccr2; meta analysis; lesion size; ccr2 ... See more keywords
CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer"
DOI: 10.1186/s12943-020-01165-x
Abstract: Background The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis.… read more here.
Keywords: ccl2; tumor; ccl2 ccr2; esophageal carcinogenesis ... See more keywords
Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.975367
Abstract: The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received special attention because of its function in the development and progression of cardiovascular disease. Numerous investigations have been performed over the… read more here.
Keywords: cardiovascular disease; ccl2 ccr2; ccl2; ccr2 axis ... See more keywords
The Role of CCL2/CCR2 Axis in Cerebral Ischemia-Reperfusion Injury and Treatment: From Animal Experiments to Clinical Trials
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073485
Abstract: C-C motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate inflammation. The CCL2/CCR2 signaling pathway participates in the… read more here.
Keywords: ccl2; ischemia reperfusion; ccl2 ccr2; injury ... See more keywords
CCL2, CCR2 Gene Variants and CCL2, CCR2 Serum Levels Association with Age-Related Macular Degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12071038
Abstract: Background: Age-related macular degeneration (AMD) is the most common cause of progressive and irreversible blindness in developed countries. Although the pathogenesis is not fully understood, AMD is a multifactorial pathology with an accumulation of inflammatory… read more here.
Keywords: early amd; ccl2; serum levels; ccl2 ccr2 ... See more keywords
CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Reports"
DOI: 10.3892/or.2017.6069
Abstract: Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type… read more here.
Keywords: cell; invasion; ccl2; ccr2 axis ... See more keywords