Influence of CCL2-mediated modulation of ALIX in the budding and replication of viruses from multiple families
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DOI: 10.1128/mbio.02241-25
Abstract: ABSTRACT Signaling by C-C motif ligand 2 (CCL2), a β-chemokine, modulates HIV-1 budding and release by mobilizing ALG-2-interacting protein X (ALIX) from the F-actin cytoskeleton to the cytosol. Immunodepleting CCL2 in the medium sequesters ALIX… read more here.
Keywords: replication; ccl2 signaling; release; ccl2 ... See more keywords
Repolarization of immunosuppressive macrophages by targeting SLAMF7-regulated CCL2 signaling sensitizes hepatocellular carcinoma to immunotherapy.
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DOI: 10.1158/0008-5472.can-23-3106
Abstract: Immune checkpoint inhibitors have limited efficacy in hepatocellular carcinoma (HCC). Macrophages are the most abundant immune cells in HCC, suggesting that a better understanding of the intrinsic processes by which tumor cells regulate macrophages could… read more here.
Keywords: slamf7; immunotherapy; ccl2 signaling; hcc ... See more keywords