CCL20 promotes migration and invasiveness of human cancerous breast epithelial cells in primary culture
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22693
Abstract: The relation between the tumor and its microenvironment is one of the most interesting and less understood issues. Recently, we showed a role of CCL20 chemokine in proning the healthy tissue neighboring the tumor to… read more here.
Keywords: epithelial cells; ccl20; breast epithelial; migration ... See more keywords
Anaphylatoxins enhance Th9 cell recruitment via the CCL20-CCR6 axis in IgA nephropathy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nephrology"
DOI: 10.1007/s40620-020-00708-1
Abstract: Background CD4 + T cells are involved in the pathogenesis of immunoglobulin A nephropathy (IgAN); T helper (Th) 1, Th17 and Th22 cells promote the occurrence and amplification of inflammatory reactions, while regulatory T (Treg)… read more here.
Keywords: th9 cell; c3a c5a; ccl20; th9 ... See more keywords
Activation of CCL20 and its receptor CCR6 promotes endometrium preparation for implantation and placenta development during the early pregnancy period in pigs
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.11.005
Abstract: ABSTRACT The success of implantation and placentation during early pregnancy depends on the intrauterine environment of diverse histotrophs, including nutrients, growth factors, cytokines, and chemokines. Here, we determined the functional role and signal transduction of… read more here.
Keywords: ccl20 receptor; pregnancy; ccl20; ccr6 ... See more keywords
The combined effect of IL-17F and CCL20 gene polymorphism in susceptibility to multiple sclerosis in Egypt.
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DOI: 10.1016/j.gene.2018.11.006
Abstract: BACKGROUND Levels of CCL20 and its CCR6 receptor are elevated in many autoimmune diseases which help in the recruitment of T helper (Th17) cells to site of inflammation. OBJECTIVES Determine the value of single nucleotide… read more here.
Keywords: rs763780; ccl20; effect; ccl20 gene ... See more keywords
Cyto/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.04.002
Abstract: BACKGROUND Scratch injury induces Koebner phenomenon in psoriasis. Smoking is also a risk factor for psoriasis. Keratinocytes can produce various psoriasis-related molecules including TNF, IL1 A, IL1B, IL6, IL12B, IL17C, IL23 A, IL36 A, IL36B, IL36 G, CXCL1, CXCL2,… read more here.
Keywords: scratch injury; ccl20; koebner phenomenon; cxcl8 ... See more keywords
CCL20, a direct‐acting pro‐angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV‐related liver cancer
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.09.023
Abstract: Abstract The CCL20/CCR6 chemokine/receptor axis has previously been shown to contribute to the initiation and progression of hepatocellular carcinoma (HCC) through the recruitment of CCR6‐positive leukocytes to the tumor microenvironment. In particular, high serum levels… read more here.
Keywords: pro angiogenic; hcc; ccl20; ccl20 direct ... See more keywords
Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals
Sign Up to like & getrecommendations! Published in 2020 at "Mucosal Immunology"
DOI: 10.1038/s41385-020-0286-6
Abstract: Gut CD4 + T cells are incompletely restored in most HIV-1-infected individuals on antiretroviral therapy, notably Th17 cells, a key subset in mucosal homeostasis. By contrast, gut Th22 cells are usually restored at normal frequencies.… read more here.
Keywords: infected individuals; ccl20; th17 cells; th22 cells ... See more keywords
EGFR/Ras-induced CCL20 production modulates the tumour microenvironment
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DOI: 10.1038/s41416-020-0943-2
Abstract: Background The activation of the EGFR/Ras-signalling pathway in tumour cells induces a distinct chemokine repertoire, which in turn modulates the tumour microenvironment. Methods The effects of EGFR/Ras on the expression and translation of CCL20 were… read more here.
Keywords: tumour microenvironment; production; egfr ras; ccl20 ... See more keywords
The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA‐B27‐associated uveitis
Sign Up to like & getrecommendations! Published in 2019 at "Acta Ophthalmologica"
DOI: 10.1111/aos.13835
Abstract: To determine the concentrations of the CC chemokines CCL2, CCL7, CCL8, CCL11, CCL13, CCL20, CCL24 and CCL26 in aqueous humour (AH) samples from patients with specific uveitic entities. read more here.
Keywords: ccl20; chemokines ccl8; ccl8 ccl13; local inflammatory ... See more keywords
Streptococcus gordonii-Induced miRNAs Regulate CCL20 Responses in Human Oral Epithelial Cells
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DOI: 10.1128/iai.00586-21
Abstract: The mechanisms through which oral commensal bacteria mitigates uncontrolled inflammatory responses of the oral mucosa remain unknown. Here, we show that representative oral bacterial species normally associated with oral health [S. gordonii (Sg), V. parvula… read more here.
Keywords: responses oral; gordonii; oral epithelial; epithelial cells ... See more keywords
Abstract 4779: Targeting the CCL20-CCR6 axis as a novel opportunity to stimulataneously modulate cancer stem cells and the tumor-immune infiltrate by a dual anti-cancer mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4779
Abstract: Drugs that target cancer stem cells (CSCs) are thought to be a critical component of any successful therapy against cancer. CSCs are responsible for chemoresistance, metastasis, and ultimately relapse of the cancer, even after an… read more here.
Keywords: ccl20; ccr6; cancer; stem cells ... See more keywords