Benzofuran‐2‐Carboxamide Derivatives as Immunomodulatory Agents Blocking the CCL20‐Induced Chemotaxis and Colon Cancer Growth
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DOI: 10.1002/cmdc.202400389
Abstract: The correlation between the CCL20/CCR6 axis and autoimmune and non‐autoimmune disorders is widely recognized. Inhibition of the CCL20‐dependent cell migration represents therefore a promising approach for the treatment of many diseases, such as inflammatory bowel… read more here.
Keywords: cancer; ccl20 induced; induced chemotaxis; ccl20 ... See more keywords
CCL20 promotes migration and invasiveness of human cancerous breast epithelial cells in primary culture
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DOI: 10.1002/mc.22693
Abstract: The relation between the tumor and its microenvironment is one of the most interesting and less understood issues. Recently, we showed a role of CCL20 chemokine in proning the healthy tissue neighboring the tumor to… read more here.
Keywords: epithelial cells; ccl20; breast epithelial; migration ... See more keywords
Anaphylatoxins enhance Th9 cell recruitment via the CCL20-CCR6 axis in IgA nephropathy
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DOI: 10.1007/s40620-020-00708-1
Abstract: Background CD4 + T cells are involved in the pathogenesis of immunoglobulin A nephropathy (IgAN); T helper (Th) 1, Th17 and Th22 cells promote the occurrence and amplification of inflammatory reactions, while regulatory T (Treg)… read more here.
Keywords: th9 cell; c3a c5a; ccl20; th9 ... See more keywords
Activation of CCL20 and its receptor CCR6 promotes endometrium preparation for implantation and placenta development during the early pregnancy period in pigs
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.11.005
Abstract: ABSTRACT The success of implantation and placentation during early pregnancy depends on the intrauterine environment of diverse histotrophs, including nutrients, growth factors, cytokines, and chemokines. Here, we determined the functional role and signal transduction of… read more here.
Keywords: ccl20 receptor; pregnancy; ccl20; ccr6 ... See more keywords
The combined effect of IL-17F and CCL20 gene polymorphism in susceptibility to multiple sclerosis in Egypt.
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DOI: 10.1016/j.gene.2018.11.006
Abstract: BACKGROUND Levels of CCL20 and its CCR6 receptor are elevated in many autoimmune diseases which help in the recruitment of T helper (Th17) cells to site of inflammation. OBJECTIVES Determine the value of single nucleotide… read more here.
Keywords: rs763780; ccl20; effect; ccl20 gene ... See more keywords
Cyto/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.04.002
Abstract: BACKGROUND Scratch injury induces Koebner phenomenon in psoriasis. Smoking is also a risk factor for psoriasis. Keratinocytes can produce various psoriasis-related molecules including TNF, IL1 A, IL1B, IL6, IL12B, IL17C, IL23 A, IL36 A, IL36B, IL36 G, CXCL1, CXCL2,… read more here.
Keywords: scratch injury; ccl20; koebner phenomenon; cxcl8 ... See more keywords
CCL20, a direct‐acting pro‐angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV‐related liver cancer
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.09.023
Abstract: Abstract The CCL20/CCR6 chemokine/receptor axis has previously been shown to contribute to the initiation and progression of hepatocellular carcinoma (HCC) through the recruitment of CCR6‐positive leukocytes to the tumor microenvironment. In particular, high serum levels… read more here.
Keywords: pro angiogenic; hcc; ccl20; ccl20 direct ... See more keywords
Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals
Sign Up to like & getrecommendations! Published in 2020 at "Mucosal Immunology"
DOI: 10.1038/s41385-020-0286-6
Abstract: Gut CD4 + T cells are incompletely restored in most HIV-1-infected individuals on antiretroviral therapy, notably Th17 cells, a key subset in mucosal homeostasis. By contrast, gut Th22 cells are usually restored at normal frequencies.… read more here.
Keywords: infected individuals; ccl20; th17 cells; th22 cells ... See more keywords
EGFR/Ras-induced CCL20 production modulates the tumour microenvironment
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DOI: 10.1038/s41416-020-0943-2
Abstract: Background The activation of the EGFR/Ras-signalling pathway in tumour cells induces a distinct chemokine repertoire, which in turn modulates the tumour microenvironment. Methods The effects of EGFR/Ras on the expression and translation of CCL20 were… read more here.
Keywords: tumour microenvironment; production; egfr ras; ccl20 ... See more keywords
CCL20 expression is elevated in inflammatory bowel disease and attenuated by vitamin D metabolites
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DOI: 10.1038/s41598-025-05094-x
Abstract: Intestinal epithelial overexpression of the Th17 cell chemoattractant CCL20 is implicated in inflammatory bowel disease and influenced by NOD2 mutations in Crohn’s disease. Vitamin D metabolites have been shown to ameliorate inflammatory bowel disease. Considering… read more here.
Keywords: disease; crohn disease; bowel disease; ccl20 ... See more keywords
The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA‐B27‐associated uveitis
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DOI: 10.1111/aos.13835
Abstract: To determine the concentrations of the CC chemokines CCL2, CCL7, CCL8, CCL11, CCL13, CCL20, CCL24 and CCL26 in aqueous humour (AH) samples from patients with specific uveitic entities. read more here.
Keywords: ccl20; chemokines ccl8; ccl8 ccl13; local inflammatory ... See more keywords