CCL19 with CCL21‐tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2vma0118-008r
Abstract: CCL19 is more potent than CCL21 in inducing chemotaxis of human dendritic cells (DC). This difference is attributed to 1) a stronger interaction of the basic C‐terminal tail of CCL21 with acidic glycosaminoglycans (GAGs) in… read more here.
Keywords: potency; ccl21 tail; ccl19 ccl21; tail ... See more keywords
Intratumor injection of CCL21-coupled vault nanoparticles is associated with reduction in tumor volume in an in vivo model of glioma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03479-8
Abstract: Purpose Glioblastoma (GBM) is the most common and malignant primary adult brain tumor. Current care includes surgical resection, radiation, and chemotherapy. Recent clinical trials for GBM have demonstrated extended survival using interventions such as tumor… read more here.
Keywords: vault; tumor volume; model; vault nanoparticles ... See more keywords
Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.04.004
Abstract: Navigation of cells along gradients of guidance cues is a determining step in many developmental and immunological processes. Gradients can either be soluble or immobilized to tissues as demonstrated for the haptotactic migration of dendritic… read more here.
Keywords: noise ratio; dendritic cells; governed signal; ccl21 ... See more keywords
Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134802
Abstract: BACKGROUND Neuroinflammation in the spinal cord is a pathological event in remifentanil-induced hyperalgesia (RIH), but its underlying molecular mechanisms remain unclear. Recent studies recapitulate the significance of the intracellular protease caspase-6 in the release of… read more here.
Keywords: caspase; spinal caspase; ccl21 cxcr3; hyperalgesia ... See more keywords
FRI0431 Dysregulation of lymphangiogenetic factors in systemic sclerosis patients with pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4972
Abstract: Background Pulmonary arterial hypertension (PAH) continues to be a major complication in systemic sclerosis (SSc); indicating an unmet need for rational therapeutic targets. Recently, we found that chemokine CCL21 was upregulated in SSc and associated… read more here.
Keywords: ssc; vegf; pulmonary arterial; hypertension ... See more keywords
Abstract CT226: A Phase I trial ofin situvaccination with autologousCCL21-modified dendritic cells (CCL21-DC) combined with pembrolizumab for advanced NSCLC
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Trials"
DOI: 10.1158/1538-7445.am2019-ct226
Abstract: Background: The majority of NSCLC patients do not respond to single agent PD-1/PD-L1 inhibitors, in part due to the lack of cytolytic T cell infiltration at the tumor site. To improve the efficacy of checkpoint… read more here.
Keywords: ccl21; phase trial; combined pembrolizumab; cell ... See more keywords
Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2020003192
Abstract: The release of newly selected αβT cells from the thymus is key in establishing a functional adaptive immune system. Emigration of the first cohorts of αβT cells produced during the neonatal period is of particular… read more here.
Keywords: production; thymus; emigration; ccl21 ... See more keywords
Nurse-like cells sequester B cells in chronic lymphocytic leukemia disorganized lymph nodes via an alternative production of CCL21.
Sign Up to like & getrecommendations! Published in 2022 at "Blood advances"
DOI: 10.1182/bloodadvances.2021006169
Abstract: Tumor microenvironment exerts critical roles in sustaining homing, retention and survival of chronic lymphocytic leukemia (CLL) cells in secondary lymphoid organs. Such conditions foster immune surveillance escape as well as resistance to current therapies. The… read more here.
Keywords: ccl21; lymphocytic leukemia; nurse like; lymph nodes ... See more keywords
Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16311
Abstract: Podoplanin (PDPN), an O-glycosylated, transmembrane, mucin-type glycoprotein, is expressed by cancer associated fibroblasts (CAFs). In malignant transformation, PDPN is subjected to changes and its role is yet to be established. Here we show that it… read more here.
Keywords: ccl21 ccr7; pdpn; ccr7; ccl21 ... See more keywords
Activation of CCL21-GPR174/CCR7 on cardiac fibroblasts underlies myocardial ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.946524
Abstract: Background: The mechanisms underlying myocardial ischemia/reperfusion (I/R) injury are not fully understood. This study aims to explore key candidate genes and potential therapeutic targets for treatment of myocardial I/R injury. Methods: The transcriptional profiles of… read more here.
Keywords: ischemia reperfusion; injury; ccl21; gpr174 ccr7 ... See more keywords
CCL21/CCR7 Axis Contributes to Trophoblastic Cell Migration and Invasion in Preeclampsia by Affecting the Epithelial Mesenchymal Transition via the ERK1/2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12020150
Abstract: Simple Summary Preeclampsia is a severe complication of human pregnancy. Despite intensive research efforts, effective treatment is still lacking. Impaired extravillous trophoblast invasion and incomplete spiral artery remodeling are thought to be the initial factors… read more here.
Keywords: ccl21; signaling pathway; erk1 signaling; migration invasion ... See more keywords