CCL19 with CCL21‐tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2vma0118-008r
Abstract: CCL19 is more potent than CCL21 in inducing chemotaxis of human dendritic cells (DC). This difference is attributed to 1) a stronger interaction of the basic C‐terminal tail of CCL21 with acidic glycosaminoglycans (GAGs) in… read more here.
Keywords: potency; ccl21 tail; ccl19 ccl21; tail ... See more keywords
Intratumor injection of CCL21-coupled vault nanoparticles is associated with reduction in tumor volume in an in vivo model of glioma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03479-8
Abstract: Purpose Glioblastoma (GBM) is the most common and malignant primary adult brain tumor. Current care includes surgical resection, radiation, and chemotherapy. Recent clinical trials for GBM have demonstrated extended survival using interventions such as tumor… read more here.
Keywords: vault; tumor volume; model; vault nanoparticles ... See more keywords
Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.04.004
Abstract: Navigation of cells along gradients of guidance cues is a determining step in many developmental and immunological processes. Gradients can either be soluble or immobilized to tissues as demonstrated for the haptotactic migration of dendritic… read more here.
Keywords: noise ratio; dendritic cells; governed signal; ccl21 ... See more keywords
Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134802
Abstract: BACKGROUND Neuroinflammation in the spinal cord is a pathological event in remifentanil-induced hyperalgesia (RIH), but its underlying molecular mechanisms remain unclear. Recent studies recapitulate the significance of the intracellular protease caspase-6 in the release of… read more here.
Keywords: caspase; spinal caspase; ccl21 cxcr3; hyperalgesia ... See more keywords
FRI0431 Dysregulation of lymphangiogenetic factors in systemic sclerosis patients with pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4972
Abstract: Background Pulmonary arterial hypertension (PAH) continues to be a major complication in systemic sclerosis (SSc); indicating an unmet need for rational therapeutic targets. Recently, we found that chemokine CCL21 was upregulated in SSc and associated… read more here.
Keywords: ssc; vegf; pulmonary arterial; hypertension ... See more keywords
Characteristics of a CCL21-gene modified dendritic cell vaccine utilized for a clinical trial in non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-24-0435
Abstract: The treatment of non-small cell lung cancer has made major strides with the use of immune checkpoint inhibitors, but there remains a significant need for therapies that can overcome immunotherapy resistance. Dendritic cell (DC) vaccines… read more here.
Keywords: non small; cancer; ccl21; small cell ... See more keywords
Abstract CT226: A Phase I trial ofin situvaccination with autologousCCL21-modified dendritic cells (CCL21-DC) combined with pembrolizumab for advanced NSCLC
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Trials"
DOI: 10.1158/1538-7445.am2019-ct226
Abstract: Background: The majority of NSCLC patients do not respond to single agent PD-1/PD-L1 inhibitors, in part due to the lack of cytolytic T cell infiltration at the tumor site. To improve the efficacy of checkpoint… read more here.
Keywords: ccl21; phase trial; combined pembrolizumab; cell ... See more keywords
Abstract CT153: Phase I trial of intratumoral administration of autologous CCL21 gene-modified dendritic cells in combination with pembrolizumab for advanced NSCLC: Feasibility of repeated IT injections
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-ct153
Abstract: Background: Effective immunotherapy options are lacking for patients with advanced non-small cell lung cancer (NSCLC) who progress on a programmed cell death-(ligand)1 [PD-(L)1] inhibitor and for those who are epidermal growth factor receptor (EGFR) mutation… read more here.
Keywords: phase trial; pembrolizumab; trial; ccl21 ... See more keywords
Abstract 7051: CCL21 therapy in conjunction with low-dose metronomic cyclophosphamide generates superior responses against neuroblastoma in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-7051
Abstract: Neuroblastoma is a pediatric malignancy that arises from aberrant neural crest progenitor cell division and proliferation. Relapsed and refractory disease often has a poor prognosis, with the long-term survival rate less than 30%. Neuroblastoma is… read more here.
Keywords: low dose; cyclophosphamide; ccl21; tumor ... See more keywords
CCL21 Enhances Platelet Activation and Atherothrombosis via CCR7 Activation.
Sign Up to like & getrecommendations! Published in 2025 at "Circulation research"
DOI: 10.1161/circresaha.125.326784
Abstract: BACKGROUND The homeostatic chemokine CCL21 (C-C motif chemokine ligand 21) is abnormally elevated in coronary artery disease. Plasma CCL21 levels have been found to be independently associated with adverse outcomes after acute coronary syndrome. However,… read more here.
Keywords: ccl21; activation; platelet activation; thrombosis ... See more keywords
Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2020003192
Abstract: The release of newly selected αβT cells from the thymus is key in establishing a functional adaptive immune system. Emigration of the first cohorts of αβT cells produced during the neonatal period is of particular… read more here.
Keywords: production; thymus; emigration; ccl21 ... See more keywords