Bulk and single-cell RNA-sequencing analyses revealed potential key genes and the role of CCL19/CCL21-CCR7 axis in hidradenitis suppurativa
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DOI: 10.1371/journal.pone.0322565
Abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder, affecting the pilosebaceous unit in apocrine gland-rich areas, characterized by painful nodules, abscesses and draining tunnels. The underlying molecular and immunological mechanisms remain poorly understood. This… read more here.
Keywords: role; ccl19 ccl21; ccr7 axis; ccr7 ... See more keywords
Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization
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DOI: 10.18632/oncotarget.16311
Abstract: Podoplanin (PDPN), an O-glycosylated, transmembrane, mucin-type glycoprotein, is expressed by cancer associated fibroblasts (CAFs). In malignant transformation, PDPN is subjected to changes and its role is yet to be established. Here we show that it… read more here.
Keywords: ccl21 ccr7; pdpn; ccr7; ccl21 ... See more keywords