CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104800
Abstract: The HBV-initiated hepatocellular carcinoma (HCC) frequently develops from or accompanies long-term chronic hepatitis, inflammation, and cirrhosis, and has a poor prognosis. Sorafenib, an orally active multi-kinase inhibitor, currently the most common approved drug for first-line… read more here.
Keywords: hepatocellular carcinoma; ccl22 signaling; ccl22; sorafenib resistance ... See more keywords
circ_0004140 promotes LUAD tumor progression and immune resistance through circ_0004140/miR-1184/CCL22 axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00983-w
Abstract: Lung adenocarcinoma (LUAD) is a highly prevalent cancer with high mortality. Immune resistance and tumor metastasis are the pivotal factors for the promotion of LUAD. CircRNAs have been revealed a crucial pre-clinical diagnostic and therapeutic… read more here.
Keywords: circ 0004140; immune resistance; resistance; mir 1184 ... See more keywords
MicroRNA-15a/16-1 Prevents Hepatocellular Carcinoma by Disrupting the Communication between Kupffer Cells and Tregs.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.10.015
Abstract: BACKGROUND & AIMS Hepatocellular carcinoma (HCC) is characterized by intratumoral accumulation of regulatory T-cells (Tregs), which suppresses antitumor immunity. This study was designed to investigate how microRNAs regulate immunosuppression in HCC. METHODS FVB/NJ mice were… read more here.
Keywords: ras myc; akt ras; hepatocellular carcinoma; hcc ... See more keywords
CCL22-expressing Stem Cell-derived Islet Grafts Recruit Regulatory T Cells in Mice.
Sign Up to like & getrecommendations! Published in 2025 at "Transplantation"
DOI: 10.1097/tp.0000000000005463
Abstract: Background. Cell therapy using human donor or stem cell–derived islets (SC-islets) to replace lost insulin-producing beta (β) cells holds great promise for type 1 diabetes. Recruiting regulatory T cells (Treg) through chemokine signaling could mitigate… read more here.
Keywords: ccl22; stem cell; cell; islet grafts ... See more keywords
Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell-Dendritic Cell Interaction.
Sign Up to like & getrecommendations! Published in 2025 at "Immunology"
DOI: 10.1111/imm.13926
Abstract: The chemokine CCL22 is constitutively expressed at high levels in lymphoid organs, where it controls immunity by promoting contacts between dendritic cells (DC) and regulatory T cells (Treg). However, its regulation and impact in the… read more here.
Keywords: ccl22; activation; cell; immune activation ... See more keywords
Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adn5229
Abstract: There is a regional preference around lymph nodes (LNs) for adipose beiging. Here, we show that local LN removal within inguinal white adipose tissue (iWAT) greatly impairs cold-induced beiging, and this impairment can be restored… read more here.
Keywords: ccl22; chemokine ccl22; macrophage derived; derived chemokine ... See more keywords
Pleural fluid C-C class chemokines 22 and pleural effusion due to heart failure: a prospective and double-blind diagnostic accuracy test
Sign Up to like & getrecommendations! Published in 2025 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2024-002823
Abstract: Background Previous studies have indicated that C-C class chemokine ligand 22 (CCL22) is involved in the pathogenesis of tuberculous pleural effusion and malignant pleural effusion. However, the diagnostic role of pleural fluid CCL22 levels in… read more here.
Keywords: effusion; ccl22; pleural fluid; pleural effusion ... See more keywords
Abstract 5020: Therapeutic potential of an immune modulatory CCL22-based vaccine
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-5020
Abstract: CCL22 is a macrophage-derived chemokine that exerts immunosuppressive functions by the recruitment of regulatory T cells (Tregs) through the CCL22/CCR4 axis. It is expressed by cells in the tumor microenvironment (TME) in many different cancer… read more here.
Keywords: immune modulatory; cancer; tumor; ccl22 specific ... See more keywords
Abstract 5153: The role of CCL22-specific CD4 T cells in modulating the immunosuppressive tumor microenvironment in ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5153
Abstract: Background: CCL22, a macrophage-derived chemokine, is overexpressed in ovarian cancer and exerts immunosuppressive functions by the recruitment of regulatory T cells (Tregs) to the tumor microenvironment (TME). Our research group described naturally occurring T cells… read more here.
Keywords: ccl22 specific; ovarian cancer; ccl22; specific cd4 ... See more keywords
Recurrent Mutations of the C-C Motif Chemokine Ligand 22 (CCL22) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK)
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-140695
Abstract: Background: The pathogenesis of chronic lymphoproliferative disorder of NK-cells (CLPD-NK) is poorly understood. Mutations in the JAK/STAT pathway (especially STAT3) are found in 30% of patients, but the genetic or exogenous drivers responsible for other… read more here.
Keywords: expression; entity board; membership entity; mtccl22 ... See more keywords
LncRNA HOTAIR promotes proliferation, invasion and migration in NSCLC cells via the CCL22 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263997
Abstract: Long noncoding RNA (LncRNA) is a new type of regulatory RNA. LncRNA HOX antisense intergenic RNA (HOTAIR), as an oncogene in non-small cell lung cancer (NSCLC), is one of the key determinants of tumor progression.… read more here.
Keywords: cell; lncrna hotair; ccl22; hotair ... See more keywords