Chemokine ligand 28 (CCL28) negatively regulates trabecular bone mass by suppressing osteoblast and osteoclast activities
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-021-01210-9
Abstract: Bone metabolism imbalances cause bone metabolism diseases, like osteoporosis, through aging. Although some chemokines are known to be involved in bone mass regulation, many have not been investigated. Thus, the present study aimed to investigate… read more here.
Keywords: bone; osteoblast osteoclast; bone mass; osteoclast activities ... See more keywords
CCR10 expression is required for the adjuvant activity of the mucosal chemokine CCL28 when delivered in the context of an HIV-1 Env DNA vaccine.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.01.023
Abstract: An effective prophylactic vaccine targeting HIV must induce a robust humoral response and must direct the bulk of this response to the mucosa-the primary site of HIV transmission. The chemokine, CCL28, is secreted by epithelial… read more here.
Keywords: chemokine ccl28; vaccine; hiv; ccl28 ... See more keywords
Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00210-20
Abstract: Candida albicans is a commensal organism that causes life-threatening or life-altering opportunistic infections. Treatment of Candida infections is limited by the paucity of antifungal drug classes. Naturally occurring antimicrobial peptides are promising agents for drug… read more here.
Keywords: anti candida; candida; ccl28; activity ... See more keywords
Inhibition of CCL28/CCR10-mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-induced Mouse Model of Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-1108
Abstract: Chronic, non-healing skin wounds such as diabetic foot ulcers (DFUs) are common in patients with type 2 diabetes. Here, we investigated the role of chemokine CCL28 and its receptor CCR10 in downregulation of endothelial nitric… read more here.
Keywords: wound healing; ccr10; type diabetes; downregulation ... See more keywords
Neutralization of excessive CCL28 improves wound healing in diabetic mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1087924
Abstract: Introduction: Chronic, non-healing skin wounds such as diabetic foot ulcers (DFUs) are common in patients with type 2 diabetes mellitus (T2DM) and often result in limb amputation and even death. However, mechanisms by which T2DM… read more here.
Keywords: healing diabetic; wound healing; anti ccl28; diabetic mice ... See more keywords
CCL28 Enhances HSV-2 gB-Specific Th1-Polarized Immune Responses against Lethal Vaginal Challenge in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10081291
Abstract: Plasmid DNA (pDNA) represents a promising “genetic vaccine platform” capable of overcoming major histocompatibility complex barriers. We previously demonstrated that low-to-moderate doses of mucosae-associated epithelial chemokine (MEC or CCL28) as an immunomodulatory adjuvant can trigger… read more here.
Keywords: th1 polarized; immune responses; hsv specific; ccr10 ... See more keywords
CCL28 promotes breast cancer growth and metastasis through MAPK-mediated cellular anti-apoptosis and pro-metastasis
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Reports"
DOI: 10.3892/or.2017.5798
Abstract: Breast cancer is one of the most commonly diagnosed cancers worldwide and the second leading cause of cancer-related deaths among females. CCL28 (mucosa-associated epithelial chemokine, MEC), a CC subfamily chemokine, has been well studied in… read more here.
Keywords: breast cancer; metastasis; cancer; ccl28 ... See more keywords