Identification of the active portion of the CCL3 derivative reported to induce antitumor abscopal effect
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Translational Radiation Oncology"
DOI: 10.1016/j.ctro.2018.02.004
Abstract: Highlights • Injected HSP70 and a partial peptide of a CCL3 variant elicit tumor growth inhibition.• The peptide also enhances tumor growth inhibition after local irradiation.• The sequence of the peptide corresponds to the beta… read more here.
Keywords: active portion; ccl3; identification active; portion ccl3 ... See more keywords
Lack of chemokine (C‐C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.09.001
Abstract: HighlightsCCL3 lack resulted in an ineffective immune response against bacteria in the brain.There is less neutrophils infiltration into the CNS.Decrease of banded neutrophils in the blood of infected CCL3 mice.CCL3‐KO mice showed an decreased cytokine… read more here.
Keywords: meningitis; ccl3; bacterial meningitis; streptococcus pneumoniae ... See more keywords
Colorectal cancer cells promote osteoclastogenesis and bone destruction through regulating EGF/ERK/CCL3 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20201175
Abstract: Abstract Bone metastasis of colorectal cancer (CRC) cells leads to osteolysis. Aberrant activation of osteoclasts is responsible for bone resorption in tumor. In general, bone marrow-derived monocytes (BMMs) differentiate into osteoclasts, however, how CRC cells… read more here.
Keywords: ccl3; crc cells; colorectal cancer; bone ... See more keywords
02.31 Targeted inhibition of macrophage inflammatory protein 1-alpha (ccl3) prevents pit formation by human osteoclasts and potently attenuates the erosion of bone in collagen-induced arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-211050.31
Abstract: Background In patients with rheumatoid arthritis (RA), osteolysis, osteopenia and osteoporosis are predictive of a severe disease phenotype. CCL3 is a chemokine associated with inflammatory osteolytic lesions and bone resorption by osteoclasts in patients with… read more here.
Keywords: ccl3; inhibition; erosion; bone ... See more keywords
Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003793
Abstract: Background Although the antitumor efficacy of docetaxel (DTX) has long been attributed to the antimitotic activities, its impact on the tumor microenvironment (TME) has recently gained more attention. Macrophages are a major component of the… read more here.
Keywords: dtx; ccl3; chemosensitivity; breast cancer ... See more keywords
CCL3 as possible negative prognostic factor in chronic lymphocytic leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "Acta haematologica"
DOI: 10.1159/000526397
Abstract: INTRODUCTION Both microenvironmental signals from surrounding cells and changes in the genome of leukemic cells play essential role in the development of chronic lymphocytic leukemia. Nurse like cells (NLCs) are one of the important elements… read more here.
Keywords: culture; lymphocytic leukemia; ccl3; cll ... See more keywords
Multiple Myeloma Cell Defects Erythropoiesis and Results Anemia Via High Level of CCL3 in Bone Marrow Microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-139006
Abstract: Background: Anemia is the most common complication of myeloma, and is associated with worse clinical outcomes including diminished quality of life, and increased risk of morbidity and mortality. Bone marrow (BM) is the main location… read more here.
Keywords: ccl3; anemia; myeloma; myeloma cell ... See more keywords
RUNX1 and CCL3 in Diabetes Mellitus-Related Coronary Artery Disease: A Bioinformatics Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s350732
Abstract: Background Cardiovascular complications are a major cause of death and disability in patients with diabetes mellitus, but how such complications arise is unclear. Methods Weighted gene correlation network analysis (WGCNA) was performed on gene expression… read more here.
Keywords: ccl3; artery disease; analysis; diabetes mellitus ... See more keywords
CCL3/Macrophage Inflammatory Protein-1α Is Dually Involved in Parasite Persistence and Induction of a TNF- and IFNγ-Enriched Inflammatory Milieu in Trypanosoma cruzi-Induced Chronic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00306
Abstract: CCL3, a member of the CC-chemokine family, has been associated with macrophage recruitment to heart tissue and parasite control in the acute infection of mouse with Trypanosoma cruzi, the causative agent of Chagas disease. Here,… read more here.
Keywords: ccl3; heart; infected ccl3; cruzi ... See more keywords