Therapeutic implications of endoplasmic reticulum stress gene CCL3 in cervical squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-024-09949-3
Abstract: This study investigated ERS-related gene expressions in CESC, identifying two molecular subtypes, P1 and P2, and constructing a precise prognostic model based on these subtypes. TCGA's whole-genome expression profiles were used to recognize these subtypes… read more here.
Keywords: ccl3; endoplasmic reticulum; cell; gene ... See more keywords
Identification of the active portion of the CCL3 derivative reported to induce antitumor abscopal effect
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Translational Radiation Oncology"
DOI: 10.1016/j.ctro.2018.02.004
Abstract: Highlights • Injected HSP70 and a partial peptide of a CCL3 variant elicit tumor growth inhibition.• The peptide also enhances tumor growth inhibition after local irradiation.• The sequence of the peptide corresponds to the beta… read more here.
Keywords: active portion; ccl3; identification active; portion ccl3 ... See more keywords
Lack of chemokine (C‐C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.09.001
Abstract: HighlightsCCL3 lack resulted in an ineffective immune response against bacteria in the brain.There is less neutrophils infiltration into the CNS.Decrease of banded neutrophils in the blood of infected CCL3 mice.CCL3‐KO mice showed an decreased cytokine… read more here.
Keywords: meningitis; ccl3; bacterial meningitis; streptococcus pneumoniae ... See more keywords
Colorectal cancer cells promote osteoclastogenesis and bone destruction through regulating EGF/ERK/CCL3 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20201175
Abstract: Abstract Bone metastasis of colorectal cancer (CRC) cells leads to osteolysis. Aberrant activation of osteoclasts is responsible for bone resorption in tumor. In general, bone marrow-derived monocytes (BMMs) differentiate into osteoclasts, however, how CRC cells… read more here.
Keywords: ccl3; crc cells; colorectal cancer; bone ... See more keywords
02.31 Targeted inhibition of macrophage inflammatory protein 1-alpha (ccl3) prevents pit formation by human osteoclasts and potently attenuates the erosion of bone in collagen-induced arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-211050.31
Abstract: Background In patients with rheumatoid arthritis (RA), osteolysis, osteopenia and osteoporosis are predictive of a severe disease phenotype. CCL3 is a chemokine associated with inflammatory osteolytic lesions and bone resorption by osteoclasts in patients with… read more here.
Keywords: ccl3; inhibition; erosion; bone ... See more keywords
Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003793
Abstract: Background Although the antitumor efficacy of docetaxel (DTX) has long been attributed to the antimitotic activities, its impact on the tumor microenvironment (TME) has recently gained more attention. Macrophages are a major component of the… read more here.
Keywords: dtx; ccl3; chemosensitivity; breast cancer ... See more keywords
CCL3 as possible negative prognostic factor in chronic lymphocytic leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "Acta haematologica"
DOI: 10.1159/000526397
Abstract: INTRODUCTION Both microenvironmental signals from surrounding cells and changes in the genome of leukemic cells play essential role in the development of chronic lymphocytic leukemia. Nurse like cells (NLCs) are one of the important elements… read more here.
Keywords: culture; lymphocytic leukemia; ccl3; cll ... See more keywords
Multiple Myeloma Cell Defects Erythropoiesis and Results Anemia Via High Level of CCL3 in Bone Marrow Microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-139006
Abstract: Background: Anemia is the most common complication of myeloma, and is associated with worse clinical outcomes including diminished quality of life, and increased risk of morbidity and mortality. Bone marrow (BM) is the main location… read more here.
Keywords: ccl3; anemia; myeloma; myeloma cell ... See more keywords
CCL3 as a novel biomarker in the diagnosis of necrotizing enterocolitis
Sign Up to like & getrecommendations! Published in 2024 at "BMC Pediatrics"
DOI: 10.1186/s12887-024-05307-8
Abstract: Neonatal necrotizing enterocolitis (NEC) is a common intestinal disease that threatens the lives of newborns and is characterized by ischemic necrosis of the small intestine and colon. As early diagnosis of NEC improves prognosis, the… read more here.
Keywords: diagnosis; necrotizing enterocolitis; ccl3; biomarker diagnosis ... See more keywords
Plasma CCL3 predicts adverse heart failure outcomes in patients with arrhythmogenic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2025 at "BMC Medicine"
DOI: 10.1186/s12916-025-04024-y
Abstract: Fibro-fatty replacement of the myocardium plays a key role in the pathogenesis of arrhythmogenic cardiomyopathy (ACM) and may be associated with progressive heart failure (HF). We aimed to investigate the characteristic of the fibro-fatty tissues… read more here.
Keywords: ccl3; acm patients; fatty tissues; patients acm ... See more keywords
RUNX1 and CCL3 in Diabetes Mellitus-Related Coronary Artery Disease: A Bioinformatics Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s350732
Abstract: Background Cardiovascular complications are a major cause of death and disability in patients with diabetes mellitus, but how such complications arise is unclear. Methods Weighted gene correlation network analysis (WGCNA) was performed on gene expression… read more here.
Keywords: ccl3; artery disease; analysis; diabetes mellitus ... See more keywords