CCL5 confines liver regeneration by downregulating reparative macrophage-derived HGF in an FoxO3a dependent manner.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32458
Abstract: BACKGROUND AND AIMS Liver regeneration is vital for the recovery of liver function after hepatectomy. Limited regeneration capacity together with insufficient remnant liver volume is a risk factor for post-hepatectomy liver failure resulting from small-for-size… read more here.
Keywords: liver regeneration; hepatectomy; phx; ccl5 ... See more keywords
CCL5 persists in RSV stocks following sucrose‐gradient purification
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ma0320-621r
Abstract: Respiratory syncytial virus (RSV) is associated with bronchiolitis in infancy and the later development of asthma. Research on RSV in vitro requires preparation of a purified RSV stock. The objective for this work was to… read more here.
Keywords: purification; persists rsv; rsv stocks; sucrose gradient ... See more keywords
Hyperalgesic and hypoalgesic mechanisms evoked by the acute administration of CCL5 in mice
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.01.014
Abstract: We show here that the intraplantar administration of CCL5 in mice produces hyperalgesia at low doses but activates compensatory antinociceptive mechanisms at doses slightly higher. Thus, the injection of 3-10ng of CCL5 evoked thermal hyperalgesia… read more here.
Keywords: administration; mechanisms; ccl5; administration ccl5 ... See more keywords
Sulfatase 1 mediates the attenuation of Ang II‐induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2017.12.027
Abstract: &NA; Extracellular sulfatases, sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling and carcinogenesis. Chemokine CCL5 inhibits Ang II‐induced hypertensive mediators via angiotensin II (Ang II) type 2 receptor (AT2… read more here.
Keywords: ang induced; ccl5; hypertensive effects; induced hypertensive ... See more keywords
Can biomarkers in umbilical cord blood predict atopic disease at school age?
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0686-z
Abstract: The prevalence of atopic diseases including atopic dermatitis, allergic rhinitis, allergic conjunctivitis, or their combination, and allergic asthma has reached epidemic proportions in Western societies and is still growing. In general, atopic diseases impact quality… read more here.
Keywords: age; ccl5; school age; atopic disease ... See more keywords
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling
Sign Up to like & getrecommendations! Published in 2021 at "Cell Research"
DOI: 10.1038/s41422-021-00528-3
Abstract: Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression and frequent recurrence. Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche, but their function in… read more here.
Keywords: gbm; ccr5 paracrine; ccl5; paracrine signaling ... See more keywords
ALPK1 regulates streptozotocin‐induced nephropathy through CCL2 and CCL5 expressions
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14643
Abstract: ALPK1 is associated with chronic kidney disease, gout and type 2 diabetes mellitus. Raised renal ALPK1 level in patients with diabetes was reported. Accelerated fibrotic nephropathies were observed in hyperglycaemic mice with up‐regulated ALPK1. The… read more here.
Keywords: alpk1; ccl5; ccl5 expressions; ccl2 ccl5 ... See more keywords
NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abm9043
Abstract: T cell–directed cancer immunotherapy often fails to generate lasting tumor control. Harnessing additional effectors of the immune response against tumors may strengthen the clinical benefit of immunotherapies. Here, we demonstrate that therapeutic targeting of the… read more here.
Keywords: cell; immunotherapy; tissue resident; resident traits ... See more keywords
Hyperaldosteronism induces vascular injury and hypertension via CCL5/CCR5 and Nox1-derived reactive oxygen species
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732784
Abstract: Hyperaldosteronism (HA) is the most frequent cause of endocrine hypertension, however the mechanisms of the genesis of hypertension are not fully understood. CCL5 is a potent pro-inflammatory and chemotactic molecule produced by endothelial and vascular… read more here.
Keywords: ccr5; vascular injury; ccr5 nox1; hypertension ... See more keywords
Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-2913
Abstract: The tumor-promoting potential of CCL5 has been proposed but remains poorly understood. We demonstrate here that an autocrine CCL5-CCR5 axis is a major regulator of immunosuppressive myeloid cells (IMC) of both monocytic and granulocytic lineages.… read more here.
Keywords: autocrine ccl5; ccl5; ccl5 ccr5; ccr5 ... See more keywords
Abstract 1740: CCR5/CCL5 axis inhibition reverses cisplatin-chemoresistance phenotye in gastric cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1740
Abstract: Gastric cancer (GC) is an important public health problem worldwide. Advanced GC treatment is mainly based in chemotherapy with Cisplatin (CDDP). Unfortunately, the high recurrence rate of GC is predominantly attributable to chemoresistance. The CCR5/CCL5… read more here.
Keywords: ccl5 axis; ccr5 ccl5; cddp; ccl5 ... See more keywords