CCL5 confines liver regeneration by downregulating reparative macrophage-derived HGF in an FoxO3a dependent manner.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32458
Abstract: BACKGROUND AND AIMS Liver regeneration is vital for the recovery of liver function after hepatectomy. Limited regeneration capacity together with insufficient remnant liver volume is a risk factor for post-hepatectomy liver failure resulting from small-for-size… read more here.
Keywords: liver regeneration; hepatectomy; phx; ccl5 ... See more keywords
CCL5 persists in RSV stocks following sucrose‐gradient purification
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ma0320-621r
Abstract: Respiratory syncytial virus (RSV) is associated with bronchiolitis in infancy and the later development of asthma. Research on RSV in vitro requires preparation of a purified RSV stock. The objective for this work was to… read more here.
Keywords: purification; persists rsv; rsv stocks; sucrose gradient ... See more keywords
Hyperalgesic and hypoalgesic mechanisms evoked by the acute administration of CCL5 in mice
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.01.014
Abstract: We show here that the intraplantar administration of CCL5 in mice produces hyperalgesia at low doses but activates compensatory antinociceptive mechanisms at doses slightly higher. Thus, the injection of 3-10ng of CCL5 evoked thermal hyperalgesia… read more here.
Keywords: administration; mechanisms; ccl5; administration ccl5 ... See more keywords
Sulfatase 1 mediates the attenuation of Ang II‐induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2017.12.027
Abstract: &NA; Extracellular sulfatases, sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling and carcinogenesis. Chemokine CCL5 inhibits Ang II‐induced hypertensive mediators via angiotensin II (Ang II) type 2 receptor (AT2… read more here.
Keywords: ang induced; ccl5; hypertensive effects; induced hypertensive ... See more keywords
Can biomarkers in umbilical cord blood predict atopic disease at school age?
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0686-z
Abstract: The prevalence of atopic diseases including atopic dermatitis, allergic rhinitis, allergic conjunctivitis, or their combination, and allergic asthma has reached epidemic proportions in Western societies and is still growing. In general, atopic diseases impact quality… read more here.
Keywords: age; ccl5; school age; atopic disease ... See more keywords
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling
Sign Up to like & getrecommendations! Published in 2021 at "Cell Research"
DOI: 10.1038/s41422-021-00528-3
Abstract: Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression and frequent recurrence. Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche, but their function in… read more here.
Keywords: gbm; ccr5 paracrine; ccl5; paracrine signaling ... See more keywords
Comprehensive analysis of the potential biological significance of CCL5 in pan-cancer prognosis and immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-73251-9
Abstract: C-C chemokine ligand 5 (CCL5) plays a crucial role in the advancement of human cancer. Nevertheless, little is known about the multi-omics characterisation of CCL5 and its significance for the immune microenvironment and prognosis of… read more here.
Keywords: prognosis immunotherapy; cancer; ccl5; pan cancer ... See more keywords
New insight into a simple high-yielding method for the production of fully folded and functional recombinant human CCL5
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-75327-y
Abstract: Chemokines are proteins important for a range of biological processes from cell-directed migration (chemotaxis) to cell activation and differentiation. Chemokine C-C ligand 5 (CCL5) is an important pro-inflammatory chemokine attracting immune cells towards inflammatory sites… read more here.
Keywords: method; insight simple; new insight; ccl5 ... See more keywords
Targeting CCL5 Attenuates Fibrosis via Activation of PI3k/Akt Signaling Axis After Glaucoma Filtration Surgery
Sign Up to like & getrecommendations! Published in 2024 at "Current Eye Research"
DOI: 10.1080/02713683.2024.2432399
Abstract: Abstract Purpose Glaucoma filtration surgery (GFS) stands as a paramount clinical intervention for glaucoma. Nonetheless, the prevalent cause of GFS failure is filtration bleb scarring, and the role of inflammation and immune response in contributing… read more here.
Keywords: ccr5 ccl5; ccl5 antibody; filtration; ccl5 ... See more keywords
TMIC-15. Reactive Oligodendrocytes Promote Glioblastoma Progression via CCL5/CCR5-Mediated Glioma Stem Cell Maintenance
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1770
Abstract: Glioblastoma (GBM) progression is tightly linked to microenvironmental interactions that remain poorly defined. Oligodendrocyte-lineage cells (OLs), traditionally viewed as passive bystanders, are increasingly recognized in the GBM niche, yet their functional role remains unexplored. Using… read more here.
Keywords: ccr5; glioma stem; ccl5; gbm ... See more keywords
Association between CCL5, CCL11, and CCL17 polymorphisms and atopic dermatitis risk: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2024 at "Medicine"
DOI: 10.1097/md.0000000000036897
Abstract: Background: Atopic dermatitis (AD) is a common and recurrent inflammatory disease with strong genetic susceptibility. The abnormal production of chemokines plays an important role in the occurrence and development of AD. Methods: A comprehensive online… read more here.
Keywords: risk; ccl5; model; association ... See more keywords