Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling
Sign Up to like & getrecommendations! Published in 2021 at "Cell Research"
DOI: 10.1038/s41422-021-00528-3
Abstract: Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression and frequent recurrence. Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche, but their function in… read more here.
Keywords: gbm; ccr5 paracrine; ccl5; paracrine signaling ... See more keywords
Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-2913
Abstract: The tumor-promoting potential of CCL5 has been proposed but remains poorly understood. We demonstrate here that an autocrine CCL5-CCR5 axis is a major regulator of immunosuppressive myeloid cells (IMC) of both monocytic and granulocytic lineages.… read more here.
Keywords: autocrine ccl5; ccl5; ccl5 ccr5; ccr5 ... See more keywords
Genetic polymorphisms of CCL5 and CCR5 to predict efficacy of cetuximab-based treatment in metastatic colorectal cancer patients depending on primary tumor location.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3594
Abstract: 3594Background: EGFR signaling blockade increases CCL5 expression, which attracts with tumor-infiltrating leukocytes regulating either the host-derived anti-tumor immunity or tumor progression. We ... read more here.
Keywords: genetic polymorphisms; predict efficacy; polymorphisms ccl5; ccr5 predict ... See more keywords
Gene polymorphisms of CCL3, CCL4, CCL5, and CCR5 network in metastatic colorectal cancer patients treated with regorafenib.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.199
Abstract: 199Background: We previously reported that genetic variant in the CCL5/CCR5 pathway predict efficacy of regorafenib in metastatic colorectal cancer patients (mCRC). CCL5 rs2280789 G allele and CCL5... read more here.
Keywords: metastatic colorectal; colorectal cancer; ccl5 ccr5; cancer patients ... See more keywords
Research Trends and Regulation of CCL5 in Prostate Cancer
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DOI: 10.2147/ott.s279189
Abstract: Abstract Prostate cancer (PCa) is considered as the most common cancer of urologic neoplasms, and its development and prognosis are associated with many factors. Chemokine receptor signaling combine with advances in advanced clinicopathological characteristics have… read more here.
Keywords: ccl5 ccr5; prostate cancer; ccr5 axis; cancer ... See more keywords
The CCL5/CCR5 Axis in Cancer Progression
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12071765
Abstract: Tumor cells can “hijack” chemokine networks to support tumor progression. In this context, the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5) axis is gaining increasing attention, since abnormal expression and activity of CCL5… read more here.
Keywords: cancer; ccr5; ccr5 axis; ccl5 ccr5 ... See more keywords