Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology and toxicology"
DOI: 10.1007/s10565-021-09635-8
Abstract: Hepatocyte senescence is a key event participating in the progression of alcoholic liver disease. Autophagy is a critical biological process that controls cell fates by affecting cell behaviors like senescence. Pterostilbene is a natural compound… read more here.
Keywords: hepatocyte senescence; alcoholic liver; senescence; pterostilbene ... See more keywords
CCN family member 1 (CCN1) is an early marker of infarct size and left ventricular dysfunction in STEMI patients.
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.09.019
Abstract: BACKGROUND AND AIMS CCN family member 1 (CCN1) has recently been proposed as a novel biomarker of myocardial injury, improving prediction of 30-day and one-year mortality following acute coronary syndromes. Among ST-elevation myocardial infarction (STEMI)… read more here.
Keywords: stemi patients; ccn1; infarct size;
CCN1 sensitizes esophageal cancer cells to TRAIL‐mediated apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.10.015
Abstract: Abstract TRAIL is one of the best anti‐cancer molecules in our body. It kills a variety of cancer cells that are resistant to conventional chemotherapy, without causing much negative impact on normal cells, because its… read more here.
Keywords: trail mediated; apoptosis; cancer cells; cancer ... See more keywords
CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-86228-z
Abstract: CCN1 is a matricellular protein highly expressed in esophageal squamous cell carcinoma (ESCC) but hardly detectable in esophageal adenocarcinoma (EAC). Expression of CCN1 in EAC cells leads to TRAIL-mediated apoptosis. Unlike TRAIL, which primarily triggers… read more here.
Keywords: april baff; squamous cell; ccn1; esophageal squamous ... See more keywords
CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43310
Abstract: CCN1, an extracellular protein also known as cysteine-rich protein 61 (Cyr61), is a novel pro-inflammatory factor involved in the pathogenesis of rheumatoid arthritis. As an inflammatory disease, psoriasis is characterized by keratinocyte activation-induced epidermal hyperplasia… read more here.
Keywords: p38 mapk; production; mapk signaling; psoriasis ... See more keywords
Induction of CCN1 in Growing Saccular Aneurysms: A Potential Marker Predicting Unstable Lesions.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab037
Abstract: Growing evidence has suggested that inflammatory responses promote the progression of saccular intracranial aneurysms (IAs). However, a biomarker predicting the progression has yet to be established. This study aimed to identify novel molecules upregulated during… read more here.
Keywords: phase; saccular aneurysms; marker predicting; ccn1 growing ... See more keywords
CCN1 secreted by human adipose‐derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Wound Journal"
DOI: 10.1111/iwj.14028
Abstract: The study aimed to explore the role of cellular communication network factor 1 (CCN1) an extracellular matrix protein in hADSC‐treated wound healing. Immunofluorescence and enzyme‐linked immunosorbent assays (ELISA) were used to demonstrate the secretion of… read more here.
Keywords: akt signalling; ccn1 secreted; wound healing; hadscs ... See more keywords
Astragaloside IV improves pulmonary arterial hypertension by increasing the expression of CCN1 and activating the ERK1/2 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17681
Abstract: The aim of the present study was to investigate the underlying mechanism of AS‐IV and CCN1 in PAH and to evaluate whether the protective effect of AS‐IV against PAH is associated with CCN1 and its… read more here.
Keywords: pah; expression; expression ccn1; signalling pathway ... See more keywords
The role of CCN1 in kidney-brain crosstalk
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1968
Abstract: Cognitive impairment and dementia are major global health problems of the aging human population. It is estimated that about 55 million people were living with dementia in 2019 and this number is expected to triple… read more here.
Keywords: ccn1; brain; physiology; kidney brain ... See more keywords
Cysteine-Rich Protein 61 (CCN1) Deficiency Alleviated Cardiac Remodeling in 5/6 Nephrectomized Mice by Suppressing the MAPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular Therapeutics"
DOI: 10.1155/cdr/6813183
Abstract: Background: With the progression of chronic kidney disease (CKD), we can often observe cardiac remodeling, fibrosis, and cardiac failure in patients. Cysteine-rich protein 61 (CCN1) is an extracellular matrix protein that plays a reuse role… read more here.
Keywords: ccn1; protein ccn1; cardiac remodeling; rich protein ... See more keywords
Prognostic Significance of Serum Cysteine-Rich Protein 61 in Patients with Acute Heart Failure
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000491984
Abstract: Background/Aims: Cyr61-cysteine-rich protein 61 (CCN1/CYR61) is a multifunctional matricellular protein involved in the regulation of fibrogenesis. Animal experiments have demonstrated that CCN1 can inhibit cardiac fibrosis in cardiac hypertrophy. However, no study has been conducted… read more here.
Keywords: protein; serum ccn1; cysteine rich; ccn1 ... See more keywords