Elevated reactive aggression in forebrain‐specific Ccn2 knockout mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cell Communication and Signaling"
DOI: 10.1002/ccs3.12040
Abstract: Abstract Cellular communication network factor 2 (CCN2) is a matricellular protein that plays important roles in connective tissue. CCN2 is also expressed in the nervous system; however, its role is still unclear. To explore CCN2… read more here.
Keywords: forebrain specific; mice; specific ccn2; ccn2 ... See more keywords
CCN2 Facilitates IL‐17 Production and Osteoclastogenesis in Human Osteoarthritis Synovial Fibroblasts by Inhibiting miR‐655 Expression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4661
Abstract: Osteoarthritis (OA) is associated with extensive upregulation of osteoclastogenesis and subsequent bone breakdown. The CCN family protein connective tissue growth factor (CCN2, also called CCN2) enhances inflammatory cytokine production in OA disease. The cytokine interleukin… read more here.
Keywords: osteoclastogenesis; mir 655; expression; production ... See more keywords
Construction of a Localized and Long-Acting CCN2 Delivery System on Percutaneous Ti Implant Surfaces for Enhanced Soft-Tissue Integration.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c00884
Abstract: Soft-tissue integration (STI) plays an essential role in the long-term success of percutaneous Ti implants since it acts as a biological barrier that protects the soft and hard tissue around implants. Surface modification of Ti… read more here.
Keywords: delivery system; soft tissue; ccn2; tissue ... See more keywords
Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58568-x
Abstract: Inhaled therapeutics have high potential for the treatment of chronic respiratory diseases of high unmet medical need, such as idiopathic pulmonary fibrosis (IPF). Preclinical and early clinical evidence show that cellular communication network factor 2… read more here.
Keywords: treatment; ccn2; protein; inhaled anti ... See more keywords
High glucose–induced Smad3 linker phosphorylation and CCN2 expression are inhibited by dapagliflozin in a diabetic tubule epithelial cell model
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience Reports"
DOI: 10.1042/bsr20203947
Abstract: Abstract Background: In the kidney glucose is freely filtered by the glomerulus and, mainly, reabsorbed by sodium glucose cotransporter 2 (SGLT2) expressed in the early proximal tubule. Human proximal tubule epithelial cells (PTECs) undergo pathological… read more here.
Keywords: glucose tgf; ccn2; glucose; tubule ... See more keywords
P147 M2 macrophage associated fibrosis in early stage systemic sclerosis: an update on plasma biomarkers
Sign Up to like & getrecommendations! Published in 2024 at "Rheumatology"
DOI: 10.1093/rheumatology/keae163.186
Abstract: Systemic sclerosis is an autoimmune connective tissue disease characterised by vasculopathy and fibrosis. The CCN family of matricellular proteins have a regulatory role in inflammation and fibrosis. CD206, an M2 macrophage surface marker, is cleaved… read more here.
Keywords: ccn2; none; early stage; stage ... See more keywords
Abstract 4138019: eQTL Analysis of the PAH Biomarker CCN2 Identifies a Novel SNP that Associates with Survival
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4138019
Abstract: Background: We recently determined that cellular communication network factor 2 (CCN2) (also known as IGFBP8) levels associate with metrics of severity, and survival, in pulmonary arterial hypertension (PAH). While genetic variants that modify CCN2 gene… read more here.
Keywords: pah; ccn2; analysis; risk ... See more keywords
Abstract 4140096: CCN2 Correlates with Early Markers of Right Ventricular Dysfunction in Adults with Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4140096
Abstract: Introduction: Cellular Communication Network 2 (CCN2, also known as CTGF and IGFBP8) is a cysteine-rich secreted matrix protein with four tandem modules and is an upstream regulator of TGFß, a key pathogenic molecule in pulmonary… read more here.
Keywords: ccn2; ccn2 levels; right ventricular; arterial hypertension ... See more keywords
CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.121.18201
Abstract: Supplemental Digital Content is available in the text. Background: CCN2 (cellular communication network factor 2) is a matricellular protein involved in cell communication and microenvironmental signaling responses. CCN2 is known to be overexpressed in several… read more here.
Keywords: ccn2; communication network; network factor; communication ... See more keywords
CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.162987
Abstract: Vascular smooth muscle cell (SMC) phenotypic switching is widely recognized as a key mechanism responsible for the pathogenesis of several aortic diseases, such as aortic aneurysm. Cellular communication network factor 2 (CCN2), often upregulated in… read more here.
Keywords: smooth muscle; ccn2; smc; ccn2 deficiency ... See more keywords
Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173191
Abstract: The potential involvement of connective tissue growth factor (CCN2/CTGF) in extracellular matrix (ECM) production is recognized. However, the role CCN2 in fibronectin (FN) gene expression has remained incompletely understood and even controversial. Here we report… read more here.
Keywords: skin dermal; human skin; ccn2; expression ... See more keywords