Articles with "ccn2" as a keyword



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CCN2 Facilitates IL‐17 Production and Osteoclastogenesis in Human Osteoarthritis Synovial Fibroblasts by Inhibiting miR‐655 Expression

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Published in 2022 at "Journal of Bone and Mineral Research"

DOI: 10.1002/jbmr.4661

Abstract: Osteoarthritis (OA) is associated with extensive upregulation of osteoclastogenesis and subsequent bone breakdown. The CCN family protein connective tissue growth factor (CCN2, also called CCN2) enhances inflammatory cytokine production in OA disease. The cytokine interleukin… read more here.

Keywords: osteoclastogenesis; mir 655; expression; production ... See more keywords
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Construction of a Localized and Long-Acting CCN2 Delivery System on Percutaneous Ti Implant Surfaces for Enhanced Soft-Tissue Integration.

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Published in 2023 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.3c00884

Abstract: Soft-tissue integration (STI) plays an essential role in the long-term success of percutaneous Ti implants since it acts as a biological barrier that protects the soft and hard tissue around implants. Surface modification of Ti… read more here.

Keywords: delivery system; soft tissue; ccn2; tissue ... See more keywords
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High glucose–induced Smad3 linker phosphorylation and CCN2 expression are inhibited by dapagliflozin in a diabetic tubule epithelial cell model

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Published in 2021 at "Bioscience Reports"

DOI: 10.1042/bsr20203947

Abstract: Abstract Background: In the kidney glucose is freely filtered by the glomerulus and, mainly, reabsorbed by sodium glucose cotransporter 2 (SGLT2) expressed in the early proximal tubule. Human proximal tubule epithelial cells (PTECs) undergo pathological… read more here.

Keywords: glucose tgf; ccn2; glucose; tubule ... See more keywords
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CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation

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Published in 2022 at "Hypertension"

DOI: 10.1161/hypertensionaha.121.18201

Abstract: Supplemental Digital Content is available in the text. Background: CCN2 (cellular communication network factor 2) is a matricellular protein involved in cell communication and microenvironmental signaling responses. CCN2 is known to be overexpressed in several… read more here.

Keywords: ccn2; communication network; network factor; communication ... See more keywords
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CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development

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Published in 2023 at "JCI Insight"

DOI: 10.1172/jci.insight.162987

Abstract: Vascular smooth muscle cell (SMC) phenotypic switching is widely recognized as a key mechanism responsible for the pathogenesis of several aortic diseases, such as aortic aneurysm. Cellular communication network factor 2 (CCN2), often upregulated in… read more here.

Keywords: smooth muscle; ccn2; smc; ccn2 deficiency ... See more keywords
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Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts

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Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0173191

Abstract: The potential involvement of connective tissue growth factor (CCN2/CTGF) in extracellular matrix (ECM) production is recognized. However, the role CCN2 in fibronectin (FN) gene expression has remained incompletely understood and even controversial. Here we report… read more here.

Keywords: skin dermal; human skin; ccn2; expression ... See more keywords

Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

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Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0186740

Abstract: TGFbeta induces fibrogenic responses in fibroblasts. Reactive oxygen species (ROS)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) may contribute to fibrogenic responses. Here, we examine if the antioxidant N-acetylcysteine (NAC), the NOX inhibitor diphenyleneiodonium (DPI) and… read more here.

Keywords: ccn2; gkt 137831; nox1 nox4; sma ... See more keywords
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MicroRNA-584 Impairs Cellular Proliferation and Sensitizes Osteosarcoma Cells to Cisplatin and Taxanes by Targeting CCN2

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Published in 2020 at "Cancer Management and Research"

DOI: 10.2147/cmar.s246545

Abstract: Background Osteosarcoma (OS), an aggressive malignant neoplasm, exhibits osteoblastic differentiation. Cisplatin (DDP) and taxanes are among the most effective drugs for OS patients. Nevertheless, the drug resistance remains a main limitation to efficacious chemotherapy in… read more here.

Keywords: ccn2; 584 impairs; microrna 584; mir 584 ... See more keywords