CCN2/CTGF promotor activity in the developing and adult mouse eye
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DOI: 10.1007/s00441-020-03332-4
Abstract: CCN2/CTGF is a matricellular protein that is known to enhance transforming growth factor-β signaling and to induce a myofibroblast-like phenotype in a variety of cell types. Here, we investigated Ccn2/Ctgf promotor activity during development and… read more here.
Keywords: ctgf promotor; activity; ccn2 ctgf; promotor activity ... See more keywords
Complement 3a Mediates CCN2/CTGF in Human Retinal Pigment Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ophthalmology"
DOI: 10.1155/2022/3259453
Abstract: Background Complement 3 (C3) is the crucial component of the complement cascade when retina was exposed to external stimulus. Cellular communication network 2/connective tissue growth factor (CCN2/CTGF) is important in response of retinal stress and… read more here.
Keywords: ctgf; retinal pigment; ccn2 ctgf; human retinal ... See more keywords
Epigenetics and expression of key genes associated with cardiac fibrosis: NLRP3, MMP2, MMP9, CCN2/CTGF and AGT.
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DOI: 10.2217/epi-2020-0446
Abstract: Aims: Excessive inflammatory signaling and pathological remodeling of the extracellular matrix drive cardiac fibrosis and require changes in gene expression. Materials and methods: Using bioinformatics, both tissue-specific expression profiles and epigenomic profiles of some genes critical for cardiac… read more here.
Keywords: mmp9 ccn2; fibrosis; cardiac fibrosis; ccn2 ctgf ... See more keywords
CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.864433
Abstract: In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes, which contribute to its permanent… read more here.
Keywords: ctgf; optic nerve; nerve head; ccn2 ctgf ... See more keywords