Phenytoin induces connective tissue growth factor (CTGF/CCN2) production through NADPH oxidase 4-mediated latent TGFβ1 activation in human gingiva fibroblasts: Suppression by curcumin.
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DOI: 10.1111/jre.13058
Abstract: OBJECTIVE AND BACKGROUND Gingival overgrowth (GO) is a common side effect of some drugs such as anticonvulsants, immunosuppressant, and calcium channel blockers. Among them, the antiepileptic agent phenytoin is the most common agent related to… read more here.
Keywords: ccn2 synthesis; phenytoin; latent tgf; tgf activation ... See more keywords