Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell communication and signaling"
DOI: 10.1007/s12079-021-00659-7
Abstract: CCN5 is a divergent member of the cellular communication network factor (CCN) family in that it lacks the carboxyl terminal cystine knot domain common to the other CCN family members. CCN5 has been reported to… read more here.
Keywords: tissue distribution; myocardial infarction; ccn5; heart ... See more keywords
The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15789
Abstract: Atrial structural remodelling including atrial hypertrophy and fibrosis is a key mediator of atrial fibrillation (AF). We previously demonstrated that the matricellular protein CCN5 elicits anti‐fibrotic and anti‐hypertrophic effects in left ventricles under pressure overload.… read more here.
Keywords: atrial structural; ccn5; adverse atrial; protein ccn5 ... See more keywords
Abstract 3293: Exploiting PEGylation of CCN5 for tumor immunity and therapy of triple-negative breast cancer: A new and effective approach for TNBC therapy
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DOI: 10.1158/1538-7445.am2025-3293
Abstract: Triple-negative breast cancer (TNBC) is defined by a lack of expressions of three receptors. These include estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor rector 2 (HER2). TNBC accounts for ∼15-17% of… read more here.
Keywords: cancer; breast; therapy; ccn5 ... See more keywords
Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25116262
Abstract: Modified mRNAs (modRNAs) are an emerging delivery method for gene therapy. The success of modRNA-based COVID-19 vaccines has demonstrated that modRNA is a safe and effective therapeutic tool. Moreover, modRNA has the potential to treat… read more here.
Keywords: cardiac dysfunction; ccn5 gene; fibrosis; ccn5 ... See more keywords